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- W1154496468 abstract "Publisher Summary Proteoglycans are highly sulfated, containing most of the macromolecular sulfate found in animal tissues. In addition, many other glycoconjugates and proteins contain small amounts of sulfate. The biological significance of sulfate is largely unknown, but possible roles include involvement in function, recognition, and transport. Sulfation of proteoglycans requires PAPS (Adenosine 3'-phosphoadenylylphosphosulfate) and appropriate sulfotransferases. Sulfation in cultured cells is generally reduced if the levels of PAPS are lowered. This can be accomplished by incubating cells in sulfate-depleted media or by incubating cells with substances that may inhibit PAPS synthesis. A useful approach for determining such roles would be to examine cell function and behavior after the cells have been incubated under conditions that result in the production of undersulfated molecules. Although this chapter deals exclusively with proteoglycan undersulfation, the same procedures may result in the undersulfation of other substances." @default.
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- W1154496468 title "[35] Decreasing sulfation of proteoglycans produced by cultured cells" @default.
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- W1154496468 doi "https://doi.org/10.1016/0076-6879(89)79143-6" @default.
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