Matches in SemOpenAlex for { <https://semopenalex.org/work/W115574987> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W115574987 abstract "Milacemide, a secondary amine derivative, was previously demonstrated to be a substrate of MAO-B and to be insensitive to the action of copper-dependent amine oxidases. In the present study, it was investigated whether the FAD-dependent secondary amine metabolizing enzyme polyamine oxidase (PAO), could participate in the metabolism of milacemide. For this purpose, the urinary metabolic pattern of oral 14C-milacemide was determined in rats with and without pretreatment with the irreversible PAO inhibitor MDL 72527 and, for comparison, after inhibition of MAO-B by l-deprenyl. While l-deprenyl was shown to significantly decrease the urinary excretion of glycinamide and of an unknown metabolite (UK1), pretreatment with MDL 72527 did not modify the elimination of milacemide as glycinamide but produced a decrease in UK1 equal to that induced by l-deprenyl. The percent of the dose of milacemide eliminated as unchanged drug was slightly but significantly increased after PAO inhibition, though considerably less than after l-deprenyl. These data suggest that milacemide might be a substrate of PAO. If confirmed, this result would constitute the first example of the involvement of the FAD-dependent PAO in drug metabolism." @default.
- W115574987 created "2016-06-24" @default.
- W115574987 creator A5003140724 @default.
- W115574987 creator A5010091677 @default.
- W115574987 creator A5055242790 @default.
- W115574987 creator A5063328267 @default.
- W115574987 date "1990-01-01" @default.
- W115574987 modified "2023-09-25" @default.
- W115574987 title "Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide?" @default.
- W115574987 cites W1970393157 @default.
- W115574987 cites W1974261505 @default.
- W115574987 cites W2001939234 @default.
- W115574987 cites W2059732007 @default.
- W115574987 cites W2061756752 @default.
- W115574987 cites W2072282085 @default.
- W115574987 cites W2085892915 @default.
- W115574987 cites W2088235106 @default.
- W115574987 cites W2239904743 @default.
- W115574987 cites W2487663582 @default.
- W115574987 cites W2496538714 @default.
- W115574987 doi "https://doi.org/10.1007/978-3-7091-9113-2_48" @default.
- W115574987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2128509" @default.
- W115574987 hasPublicationYear "1990" @default.
- W115574987 type Work @default.
- W115574987 sameAs 115574987 @default.
- W115574987 citedByCount "0" @default.
- W115574987 crossrefType "book-chapter" @default.
- W115574987 hasAuthorship W115574987A5003140724 @default.
- W115574987 hasAuthorship W115574987A5010091677 @default.
- W115574987 hasAuthorship W115574987A5055242790 @default.
- W115574987 hasAuthorship W115574987A5063328267 @default.
- W115574987 hasConcept C117001961 @default.
- W115574987 hasConcept C181199279 @default.
- W115574987 hasConcept C185592680 @default.
- W115574987 hasConcept C2777477808 @default.
- W115574987 hasConcept C55493867 @default.
- W115574987 hasConcept C62231903 @default.
- W115574987 hasConcept C86803240 @default.
- W115574987 hasConcept C98274493 @default.
- W115574987 hasConceptScore W115574987C117001961 @default.
- W115574987 hasConceptScore W115574987C181199279 @default.
- W115574987 hasConceptScore W115574987C185592680 @default.
- W115574987 hasConceptScore W115574987C2777477808 @default.
- W115574987 hasConceptScore W115574987C55493867 @default.
- W115574987 hasConceptScore W115574987C62231903 @default.
- W115574987 hasConceptScore W115574987C86803240 @default.
- W115574987 hasConceptScore W115574987C98274493 @default.
- W115574987 hasLocation W1155749871 @default.
- W115574987 hasLocation W1155749872 @default.
- W115574987 hasOpenAccess W115574987 @default.
- W115574987 hasPrimaryLocation W1155749871 @default.
- W115574987 hasRelatedWork W1479674492 @default.
- W115574987 hasRelatedWork W1581350964 @default.
- W115574987 hasRelatedWork W196852912 @default.
- W115574987 hasRelatedWork W1988688755 @default.
- W115574987 hasRelatedWork W2051554319 @default.
- W115574987 hasRelatedWork W2069584306 @default.
- W115574987 hasRelatedWork W2077211817 @default.
- W115574987 hasRelatedWork W2272166505 @default.
- W115574987 hasRelatedWork W2900504840 @default.
- W115574987 hasRelatedWork W2949445124 @default.
- W115574987 isParatext "false" @default.
- W115574987 isRetracted "false" @default.
- W115574987 magId "115574987" @default.
- W115574987 workType "book-chapter" @default.