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- W115703098 abstract "Dyslipidemia is a central component of the Metabolic Syndrome. In the WHO and in the NCEP-ATP III definitions low HDL and hypertriglyceridemia are considered as one and two separated traits respectively. Hypertriglyceridemia, low HDL-chloesterol and small, dense LDL -called the lipid triad- are present in 40-50% of the patients with the Metabolic Syndrome. However the dyslipidemia of the Metabolic Syndrome is more complex, comprising anomalies in fatty acids regulation and changes in the pattern and composition of triglyceride-rich proteins as well as in HDL-cholesterol and LDL subfractions. The increase in the triglyceride content of LDL increases the length of their exposure to oxidation and glycation, increasing their atherogenicity. Anomalies in visceral fat cell metabolism and insulin resistance are mayor players in the underlying pathophysiology. Disturbances in VLDL synthesis and in the removal of triglyceride-rich lipoproteins are first observed in the postprandial phase, before type 2 diabetes is diagnosed. Type 2 diabetes amplifies the functional and structural changes in lipoprotein metabolism. Dyslipidemia is a prominent risk factor for both diabetes and atherosclerosis. However the full cluster of the Metabolic Syndrome confers higher risk. This speaks in favor of the hypothesis that dyslipidemia acts together with the other risk factors (diseases of the Metabolic Syndrome) in a vicious cycle. Early signals from prospective studies indicate that the strict correction of dyslipidemia may be an option for primary and secondary prevention of cardiovascular diseases and type 2 diabetes." @default.
- W115703098 created "2016-06-24" @default.
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- W115703098 date "2005-01-01" @default.
- W115703098 modified "2023-09-25" @default.
- W115703098 title "Dyslipidemia in the Metabolic Syndrome" @default.
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- W115703098 doi "https://doi.org/10.1016/b978-84-8174-892-5.50021-8" @default.
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