Matches in SemOpenAlex for { <https://semopenalex.org/work/W11580705> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W11580705 abstract "Recent studies indicate that the selected micro-and macro-elements and vitamins may significantly influence the risk of cancer. Folic acid is necessary for DNA synthesis and repair, plays an important role in one-carbon groups for methylation reactions. The MTHFR gene produces an enzyme important in folate metabolism.The aim of study was to analyze an association of folic acid concentrations and genetic variants in the MTHFR gene with breast cancer risk in patients with BRCA1 mutation.Study group consisted of 99 patients with breast or ovarian cancer and 198 healthy women from the paired control group; all cases and controls were carriers of one out of three Polish founder mutations (C61G, 4153delA, 5382insC). Folic acid concentration was quantitatively measured in blood plasma by HPLC chromatography (Flexar HPLC, Perkin Elmer). Two functional SNPs in the MTHFR gene, 677 C>T (rs1801133) and 1298 A>C (rs1801131), both associated with reduced enzyme activity, have been tested on LightCycler 480 (Roche Diagnostic) by Taqman or Simple Probe approach.The mean levels of folic acid were compared for cases and controls. Women who have level of folic acid in the range of 53.3 mg/l - 83.1 mg/l had a significantly lower risk of breast or ovarian cancer (OR = 0.55, p = 0.0087) – comparison to quartile with the lowest concentration. The analysis of correlation between the level of folic acid and tested genetic variants in the MTHFR gene gave the following results:- for carriers of MTHFR 1298AA the lowest risk of cancer was for folic acid concentration >81 mg/l (OR = 0,25, p = 0,0292 , CI = 0,07948-0,7863)Table 1- for carriers of MTHFR 1298AA +AC the lowest risk of cancer was for folic acid concentration in the range of 51,44 to 82-82 mg/l (OR = 0,25, p = 0,009, CI = 0,09-0,67)Table 2" @default.
- W11580705 created "2016-06-24" @default.
- W11580705 creator A5026014942 @default.
- W11580705 creator A5026033317 @default.
- W11580705 creator A5035411629 @default.
- W11580705 creator A5049744934 @default.
- W11580705 creator A5052050895 @default.
- W11580705 creator A5054987735 @default.
- W11580705 creator A5056748204 @default.
- W11580705 creator A5065070297 @default.
- W11580705 creator A5076955981 @default.
- W11580705 creator A5081536138 @default.
- W11580705 creator A5084943921 @default.
- W11580705 creator A5086464692 @default.
- W11580705 creator A5090925673 @default.
- W11580705 date "2012-04-20" @default.
- W11580705 modified "2023-10-10" @default.
- W11580705 title "Folic acid and cancer risk in BRCA1 carriers" @default.
- W11580705 doi "https://doi.org/10.1186/1897-4287-10-s3-a6" @default.
- W11580705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3395393" @default.
- W11580705 hasPublicationYear "2012" @default.
- W11580705 type Work @default.
- W11580705 sameAs 11580705 @default.
- W11580705 citedByCount "0" @default.
- W11580705 crossrefType "journal-article" @default.
- W11580705 hasAuthorship W11580705A5026014942 @default.
- W11580705 hasAuthorship W11580705A5026033317 @default.
- W11580705 hasAuthorship W11580705A5035411629 @default.
- W11580705 hasAuthorship W11580705A5049744934 @default.
- W11580705 hasAuthorship W11580705A5052050895 @default.
- W11580705 hasAuthorship W11580705A5054987735 @default.
- W11580705 hasAuthorship W11580705A5056748204 @default.
- W11580705 hasAuthorship W11580705A5065070297 @default.
- W11580705 hasAuthorship W11580705A5076955981 @default.
- W11580705 hasAuthorship W11580705A5081536138 @default.
- W11580705 hasAuthorship W11580705A5084943921 @default.
- W11580705 hasAuthorship W11580705A5086464692 @default.
- W11580705 hasAuthorship W11580705A5090925673 @default.
- W11580705 hasBestOaLocation W115807051 @default.
- W11580705 hasConcept C104317684 @default.
- W11580705 hasConcept C121608353 @default.
- W11580705 hasConcept C126322002 @default.
- W11580705 hasConcept C134018914 @default.
- W11580705 hasConcept C135763542 @default.
- W11580705 hasConcept C146304588 @default.
- W11580705 hasConcept C153209595 @default.
- W11580705 hasConcept C2780427987 @default.
- W11580705 hasConcept C2992130864 @default.
- W11580705 hasConcept C43563269 @default.
- W11580705 hasConcept C530470458 @default.
- W11580705 hasConcept C54355233 @default.
- W11580705 hasConcept C71924100 @default.
- W11580705 hasConcept C86803240 @default.
- W11580705 hasConceptScore W11580705C104317684 @default.
- W11580705 hasConceptScore W11580705C121608353 @default.
- W11580705 hasConceptScore W11580705C126322002 @default.
- W11580705 hasConceptScore W11580705C134018914 @default.
- W11580705 hasConceptScore W11580705C135763542 @default.
- W11580705 hasConceptScore W11580705C146304588 @default.
- W11580705 hasConceptScore W11580705C153209595 @default.
- W11580705 hasConceptScore W11580705C2780427987 @default.
- W11580705 hasConceptScore W11580705C2992130864 @default.
- W11580705 hasConceptScore W11580705C43563269 @default.
- W11580705 hasConceptScore W11580705C530470458 @default.
- W11580705 hasConceptScore W11580705C54355233 @default.
- W11580705 hasConceptScore W11580705C71924100 @default.
- W11580705 hasConceptScore W11580705C86803240 @default.
- W11580705 hasLocation W115807051 @default.
- W11580705 hasLocation W115807052 @default.
- W11580705 hasOpenAccess W11580705 @default.
- W11580705 hasPrimaryLocation W115807051 @default.
- W11580705 hasRelatedWork W1421017940 @default.
- W11580705 hasRelatedWork W1861722028 @default.
- W11580705 hasRelatedWork W1971277569 @default.
- W11580705 hasRelatedWork W1978389018 @default.
- W11580705 hasRelatedWork W1996010884 @default.
- W11580705 hasRelatedWork W2030356384 @default.
- W11580705 hasRelatedWork W2094491479 @default.
- W11580705 hasRelatedWork W2096640391 @default.
- W11580705 hasRelatedWork W2107362480 @default.
- W11580705 hasRelatedWork W2137849114 @default.
- W11580705 hasRelatedWork W2147938823 @default.
- W11580705 hasRelatedWork W2347875664 @default.
- W11580705 hasRelatedWork W2372049786 @default.
- W11580705 hasRelatedWork W2382345833 @default.
- W11580705 hasRelatedWork W2386814999 @default.
- W11580705 hasRelatedWork W2408258079 @default.
- W11580705 hasRelatedWork W2414770970 @default.
- W11580705 hasRelatedWork W2807465423 @default.
- W11580705 hasRelatedWork W3033061669 @default.
- W11580705 hasRelatedWork W313895080 @default.
- W11580705 isParatext "false" @default.
- W11580705 isRetracted "false" @default.
- W11580705 magId "11580705" @default.
- W11580705 workType "article" @default.