Matches in SemOpenAlex for { <https://semopenalex.org/work/W1158448175> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1158448175 endingPage "56" @default.
- W1158448175 startingPage "846" @default.
- W1158448175 abstract "Excessive exposure to sunlight may be a risk factor for ocular diseases and reduced visual performance. This study was designed to examine the ability of an ultraviolet (UV)-blocking spectacle lens to prevent visual acuity decline and ocular surface disorders in a mouse model of UVB-induced photokeratitis.Mice were divided into 4 groups (10 mice per group): (1) a blank control group (no exposure to UV radiation), (2) a UVB/no lens group (mice exposed to UVB rays, but without lens protection), (3) a UVB/UV400 group (mice exposed to UVB rays and protected using the CR-39™ spectacle lens [UV400 coating]), and (4) a UVB/photochromic group (mice exposed to UVB rays and protected using the CR-39™ spectacle lens [photochromic coating]). We investigated UVB-induced changes in visual acuity and in corneal smoothness, opacity, and lissamine green staining. We also evaluated the correlation between visual acuity decline and changes to the corneal surface parameters. Tissue sections were prepared and stained immunohistochemically to evaluate the structural integrity of the cornea and conjunctiva.In blank controls, the cornea remained undamaged, whereas in UVB-exposed mice, the corneal surface was disrupted; this disruption significantly correlated with a concomitant decline in visual acuity. Both the UVB/UV400 and UVB/photochromic groups had sharper visual acuity and a healthier corneal surface than the UVB/no lens group. Eyes in both protected groups also showed better corneal and conjunctival structural integrity than unprotected eyes. Furthermore, there were fewer apoptotic cells and less polymorphonuclear leukocyte infiltration in corneas protected by the spectacle lenses.The model established herein reliably determines the protective effect of UV-blocking ophthalmic biomaterials, because the in vivo protection against UV-induced ocular damage and visual acuity decline was easily defined." @default.
- W1158448175 created "2016-06-24" @default.
- W1158448175 creator A5047987643 @default.
- W1158448175 creator A5052487706 @default.
- W1158448175 creator A5052593264 @default.
- W1158448175 creator A5056843115 @default.
- W1158448175 creator A5090345658 @default.
- W1158448175 date "2015-01-01" @default.
- W1158448175 modified "2023-09-23" @default.
- W1158448175 title "UV-blocking spectacle lens protects against UV-induced decline of visual performance." @default.
- W1158448175 cites W1555649826 @default.
- W1158448175 cites W1564120607 @default.
- W1158448175 cites W1862953680 @default.
- W1158448175 cites W186735717 @default.
- W1158448175 cites W1961082235 @default.
- W1158448175 cites W1963814953 @default.
- W1158448175 cites W1975788753 @default.
- W1158448175 cites W1977954602 @default.
- W1158448175 cites W2008601975 @default.
- W1158448175 cites W2014442454 @default.
- W1158448175 cites W2014825497 @default.
- W1158448175 cites W2020999562 @default.
- W1158448175 cites W2024070862 @default.
- W1158448175 cites W2026591700 @default.
- W1158448175 cites W2047781180 @default.
- W1158448175 cites W2051743345 @default.
- W1158448175 cites W2055820698 @default.
- W1158448175 cites W2056730667 @default.
- W1158448175 cites W2058609863 @default.
- W1158448175 cites W2063720825 @default.
- W1158448175 cites W2070628315 @default.
- W1158448175 cites W2071420551 @default.
- W1158448175 cites W2079226226 @default.
- W1158448175 cites W2082652523 @default.
- W1158448175 cites W2093753065 @default.
- W1158448175 cites W2097708243 @default.
- W1158448175 cites W2121171962 @default.
- W1158448175 cites W2145808384 @default.
- W1158448175 cites W2150828480 @default.
- W1158448175 cites W2155377690 @default.
- W1158448175 cites W2165894165 @default.
- W1158448175 cites W84189979 @default.
- W1158448175 cites W2107001194 @default.
- W1158448175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4527595" @default.
- W1158448175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26283865" @default.
- W1158448175 hasPublicationYear "2015" @default.
- W1158448175 type Work @default.
- W1158448175 sameAs 1158448175 @default.
- W1158448175 citedByCount "5" @default.
- W1158448175 countsByYear W11584481752016 @default.
- W1158448175 countsByYear W11584481752017 @default.
- W1158448175 countsByYear W11584481752018 @default.
- W1158448175 countsByYear W11584481752019 @default.
- W1158448175 crossrefType "journal-article" @default.
- W1158448175 hasAuthorship W1158448175A5047987643 @default.
- W1158448175 hasAuthorship W1158448175A5052487706 @default.
- W1158448175 hasAuthorship W1158448175A5052593264 @default.
- W1158448175 hasAuthorship W1158448175A5056843115 @default.
- W1158448175 hasAuthorship W1158448175A5090345658 @default.
- W1158448175 hasConcept C118487528 @default.
- W1158448175 hasConcept C142724271 @default.
- W1158448175 hasConcept C151730666 @default.
- W1158448175 hasConcept C15336307 @default.
- W1158448175 hasConcept C2775984611 @default.
- W1158448175 hasConcept C2776882836 @default.
- W1158448175 hasConcept C2778257484 @default.
- W1158448175 hasConcept C71924100 @default.
- W1158448175 hasConcept C86803240 @default.
- W1158448175 hasConceptScore W1158448175C118487528 @default.
- W1158448175 hasConceptScore W1158448175C142724271 @default.
- W1158448175 hasConceptScore W1158448175C151730666 @default.
- W1158448175 hasConceptScore W1158448175C15336307 @default.
- W1158448175 hasConceptScore W1158448175C2775984611 @default.
- W1158448175 hasConceptScore W1158448175C2776882836 @default.
- W1158448175 hasConceptScore W1158448175C2778257484 @default.
- W1158448175 hasConceptScore W1158448175C71924100 @default.
- W1158448175 hasConceptScore W1158448175C86803240 @default.
- W1158448175 hasLocation W11584481751 @default.
- W1158448175 hasOpenAccess W1158448175 @default.
- W1158448175 hasPrimaryLocation W11584481751 @default.
- W1158448175 hasRelatedWork W1967758317 @default.
- W1158448175 hasRelatedWork W2003317690 @default.
- W1158448175 hasRelatedWork W2033719195 @default.
- W1158448175 hasRelatedWork W2156340718 @default.
- W1158448175 hasRelatedWork W2360405837 @default.
- W1158448175 hasRelatedWork W2414973788 @default.
- W1158448175 hasRelatedWork W2954016756 @default.
- W1158448175 hasRelatedWork W3029059359 @default.
- W1158448175 hasRelatedWork W4200175518 @default.
- W1158448175 hasRelatedWork W3029272414 @default.
- W1158448175 hasVolume "21" @default.
- W1158448175 isParatext "false" @default.
- W1158448175 isRetracted "false" @default.
- W1158448175 magId "1158448175" @default.
- W1158448175 workType "article" @default.