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- W1158657002 endingPage "6010" @default.
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- W1158657002 abstract "Mucosal vaccination, which is shown to elicit systemic and mucosal immune responses, serves as a non-invasive and convenient alternative to parenteral administration, with stronger capability in combatting diseases at the site of entry. The exploration of potent mucosal adjuvants is emerging as a significant area, based on the continued necessity to amplify the immune responses to a wide array of antigens that are poorly immunogenic at the mucosal sites. As one of the inspirations from the ocean, chitosan-based mucosal adjuvants have been developed with unique advantages, such as, ability of mucosal adhesion, distinct trait of opening the junctions to allow the paracellular transport of antigen, good tolerability and biocompatibility, which guaranteed the great potential in capitalizing on their application in human clinical trials. In this review, the state of art of chitosan and its derivatives as mucosal adjuvants, including thermo-sensitive chitosan system as mucosal adjuvant that were newly developed by author's group, was described, as well as the clinical application perspective. After a brief introduction of mucosal adjuvants, chitosan and its derivatives as robust immune potentiator were discussed in detail and depth, in regard to the metabolism, safety profile, mode of actions and preclinical and clinical applications, which may shed light on the massive clinical application of chitosan as mucosal adjuvant." @default.
- W1158657002 created "2016-06-24" @default.
- W1158657002 creator A5032247471 @default.
- W1158657002 creator A5075161138 @default.
- W1158657002 creator A5085480265 @default.
- W1158657002 creator A5087729175 @default.
- W1158657002 creator A5090973282 @default.
- W1158657002 date "2015-11-01" @default.
- W1158657002 modified "2023-10-06" @default.
- W1158657002 title "Chitosan-based mucosal adjuvants: Sunrise on the ocean" @default.
- W1158657002 cites W1492152058 @default.
- W1158657002 cites W1498725963 @default.
- W1158657002 cites W1533714151 @default.
- W1158657002 cites W1541781779 @default.
- W1158657002 cites W1574019439 @default.
- W1158657002 cites W1582526107 @default.
- W1158657002 cites W1824220324 @default.
- W1158657002 cites W1850775144 @default.
- W1158657002 cites W1901003958 @default.
- W1158657002 cites W1963760713 @default.
- W1158657002 cites W1963853765 @default.
- W1158657002 cites W1966081484 @default.
- W1158657002 cites W1966823964 @default.
- W1158657002 cites W1972191954 @default.
- W1158657002 cites W1972261522 @default.
- W1158657002 cites W1972288281 @default.
- W1158657002 cites W1972325925 @default.
- W1158657002 cites W1973617860 @default.
- W1158657002 cites W1973645595 @default.
- W1158657002 cites W1975773159 @default.
- W1158657002 cites W1977437107 @default.
- W1158657002 cites W1978006756 @default.
- W1158657002 cites W1978423917 @default.
- W1158657002 cites W1979973526 @default.
- W1158657002 cites W1981714645 @default.
- W1158657002 cites W1982279452 @default.
- W1158657002 cites W1984521241 @default.
- W1158657002 cites W1985286577 @default.
- W1158657002 cites W1986974927 @default.
- W1158657002 cites W1988494943 @default.
- W1158657002 cites W1988626912 @default.
- W1158657002 cites W1989268341 @default.
- W1158657002 cites W1990129537 @default.
- W1158657002 cites W1992287346 @default.
- W1158657002 cites W1992482869 @default.
- W1158657002 cites W1995013137 @default.
- W1158657002 cites W1996021143 @default.
- W1158657002 cites W1996246992 @default.
- W1158657002 cites W1996341603 @default.
- W1158657002 cites W1997154876 @default.
- W1158657002 cites W1999617488 @default.
- W1158657002 cites W2001285947 @default.
- W1158657002 cites W2001623042 @default.
- W1158657002 cites W2002392006 @default.
- W1158657002 cites W2003443332 @default.
- W1158657002 cites W2004509081 @default.
- W1158657002 cites W2008028087 @default.
- W1158657002 cites W2011843272 @default.
- W1158657002 cites W2013103459 @default.
- W1158657002 cites W2013425324 @default.
- W1158657002 cites W2018460948 @default.
- W1158657002 cites W2019374792 @default.
- W1158657002 cites W2021859397 @default.
- W1158657002 cites W2021978496 @default.
- W1158657002 cites W2022806451 @default.
- W1158657002 cites W2023025402 @default.
- W1158657002 cites W2023569724 @default.
- W1158657002 cites W2025733005 @default.
- W1158657002 cites W2026355813 @default.
- W1158657002 cites W2027601175 @default.
- W1158657002 cites W2028327533 @default.
- W1158657002 cites W2029884055 @default.
- W1158657002 cites W2030796658 @default.
- W1158657002 cites W2031544117 @default.
- W1158657002 cites W2032496099 @default.
- W1158657002 cites W2034253067 @default.
- W1158657002 cites W2034323018 @default.
- W1158657002 cites W2034783507 @default.
- W1158657002 cites W2035724912 @default.
- W1158657002 cites W2035914785 @default.
- W1158657002 cites W2035990801 @default.
- W1158657002 cites W2036239088 @default.
- W1158657002 cites W2037096236 @default.
- W1158657002 cites W2037282337 @default.
- W1158657002 cites W2038528411 @default.
- W1158657002 cites W2039806311 @default.
- W1158657002 cites W2042479857 @default.
- W1158657002 cites W2043886290 @default.
- W1158657002 cites W2046182783 @default.
- W1158657002 cites W2047033586 @default.
- W1158657002 cites W2048741406 @default.
- W1158657002 cites W2049051466 @default.
- W1158657002 cites W2050055751 @default.
- W1158657002 cites W2050590498 @default.
- W1158657002 cites W205089275 @default.
- W1158657002 cites W2051845904 @default.
- W1158657002 cites W2051977226 @default.
- W1158657002 cites W2052818607 @default.