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• W115893596 startingPage "1" @default.
• W115893596 abstract "Vitamin D is a secosteroid and is the only vitamin known to be converted to a hormone. The hormonal form of vitamin D acts, at least in part, through a nuclear-mediated mechanism. A specific receptor protein has been found for this molecule in intestine, bone, and kidney, where it is known to carry out specific actions in stimulating calcium and phosphorus transport reactions. In addition to the classic actions of vitamin D, it has been demonstrated that a number of tissues possess not only the receptor for 1,25-(OH)2D3 but also show specific nuclear localization of radiolabeled 1,25-(OH)2D3. These include the parathyroid gland cells, islet cells of the pancreas, certain cell types of the pituitary, brain cells, odonoblasts, endocrine cells of the stomach, epidermal cells of the skin, and epithelial cells of mammary tissue. Recent developments have shown that 1,25-(OH)2D3 causes differentiation of myeloid leukemia cells into monocytes. There is also additional evidence that these monocytes accumulate into multinuclear cells perhaps as an osteoclast precursor. Again, the molecular mechanism of action of 1,25-(OH)2D3 in these responses remains unknown." @default.
• W115893596 created "2016-06-24" @default.
• W115893596 creator A5003873771 @default.
• W115893596 creator A5055564468 @default.
• W115893596 date "1985-01-01" @default.
• W115893596 modified "2023-09-27" @default.
• W115893596 title "The Vitamin D Receptor" @default.
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