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- W1159008209 abstract "The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic programs that orchestrate biological processes to promote growth and proliferation. Altered metabolism characterized by heightened nutrients uptake, enhanced glycolysis and glutaminolysis and elevated fatty acid and nucleotide synthesis is the hallmark of MYC-driven cancer. Recent evidence strongly suggests that Myc-dependent metabolic reprogramming is critical for tumorigenesis, which could be attenuated by targeting specific metabolic pathways using small drug-like molecules. Understanding the complexity of MYC-mediated metabolic re-wiring in cancers as well as how MYC cooperates with other metabolic drivers such as mammalian target of rapamycin (mTOR) will provide translational opportunities for cancer therapy." @default.
- W1159008209 created "2016-06-24" @default.
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- W1159008209 creator A5048286196 @default.
- W1159008209 creator A5058008885 @default.
- W1159008209 creator A5079265940 @default.
- W1159008209 date "2015-07-01" @default.
- W1159008209 modified "2023-10-11" @default.
- W1159008209 title "MYC and metabolism on the path to cancer" @default.
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