Matches in SemOpenAlex for { <https://semopenalex.org/work/W115921675> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W115921675 endingPage "75" @default.
- W115921675 startingPage "161" @default.
- W115921675 abstract "Metallothioneins that bind copper and zinc have an Mr of 6500 daltons, consist of a single polypeptide chain of 61 amino acids, 25-30 percent of whose residues are cysteine, have a metal-binding capacity of between 5 and 7 g atoms/mol, and contain no disulfide bonds or aromatic amino acids. Zincthionein has been postulated to participate in the transport and storage of zinc, which is involved in more than 235 metalloenzymes, including thymidine kinase, RNA polymerase, and ribonuclease, which in turn play crucial roles in the replication and transcription of DNA during cell division. In addition, trace elements including zinc modulate immune response and function. Conversely, zinc deficiency state causes, for example, thymic atrophy and lymphopenia and modifies antibody-mediated responses to both T-cell-dependent and T-cell-independent antigens. The concentrations of copper, zinc, and metallothionein and the copper/zinc ratio are modified in a number of malignancies. For example, the levels of metallothionein in normal and in malignant human livers are 471 and 75 micrograms/g, respectively. In addition, the copper/zinc ratio is significantly increased in human pancreatic cancer from 1.40 to 2.70. Furthermore, studies involving 64Cu in tumor-bearing mice showed that the distribution of 64Cu was altered and that all tumors contained a relatively high level of 64Cu. Moreover, the activity of superoxide dismutase to remove free oxygen radicals is lower in malignant tissues. Finally, the results of clinical studies suggest that the monitoring of the serum copper/zinc ratio may be a valuable tool, not only in determining the extent of malignancies, but also in predicting the efficacy of treatments." @default.
- W115921675 created "2016-06-24" @default.
- W115921675 creator A5000440445 @default.
- W115921675 creator A5085226245 @default.
- W115921675 date "1988-01-01" @default.
- W115921675 modified "2023-09-25" @default.
- W115921675 title "The status of zinc, copper, and metallothionein in cancer patients." @default.
- W115921675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3283743" @default.
- W115921675 hasPublicationYear "1988" @default.
- W115921675 type Work @default.
- W115921675 sameAs 115921675 @default.
- W115921675 citedByCount "24" @default.
- W115921675 countsByYear W1159216752012 @default.
- W115921675 countsByYear W1159216752013 @default.
- W115921675 countsByYear W1159216752014 @default.
- W115921675 countsByYear W1159216752015 @default.
- W115921675 countsByYear W1159216752016 @default.
- W115921675 countsByYear W1159216752017 @default.
- W115921675 countsByYear W1159216752018 @default.
- W115921675 countsByYear W1159216752019 @default.
- W115921675 countsByYear W1159216752020 @default.
- W115921675 countsByYear W1159216752022 @default.
- W115921675 countsByYear W1159216752023 @default.
- W115921675 crossrefType "journal-article" @default.
- W115921675 hasAuthorship W115921675A5000440445 @default.
- W115921675 hasAuthorship W115921675A5085226245 @default.
- W115921675 hasConcept C153911025 @default.
- W115921675 hasConcept C17165728 @default.
- W115921675 hasConcept C178790620 @default.
- W115921675 hasConcept C181199279 @default.
- W115921675 hasConcept C185592680 @default.
- W115921675 hasConcept C20719415 @default.
- W115921675 hasConcept C2775838275 @default.
- W115921675 hasConcept C2776151105 @default.
- W115921675 hasConcept C2779201268 @default.
- W115921675 hasConcept C515207424 @default.
- W115921675 hasConcept C535196362 @default.
- W115921675 hasConcept C544778455 @default.
- W115921675 hasConcept C55493867 @default.
- W115921675 hasConcept C86803240 @default.
- W115921675 hasConceptScore W115921675C153911025 @default.
- W115921675 hasConceptScore W115921675C17165728 @default.
- W115921675 hasConceptScore W115921675C178790620 @default.
- W115921675 hasConceptScore W115921675C181199279 @default.
- W115921675 hasConceptScore W115921675C185592680 @default.
- W115921675 hasConceptScore W115921675C20719415 @default.
- W115921675 hasConceptScore W115921675C2775838275 @default.
- W115921675 hasConceptScore W115921675C2776151105 @default.
- W115921675 hasConceptScore W115921675C2779201268 @default.
- W115921675 hasConceptScore W115921675C515207424 @default.
- W115921675 hasConceptScore W115921675C535196362 @default.
- W115921675 hasConceptScore W115921675C544778455 @default.
- W115921675 hasConceptScore W115921675C55493867 @default.
- W115921675 hasConceptScore W115921675C86803240 @default.
- W115921675 hasLocation W1159216751 @default.
- W115921675 hasOpenAccess W115921675 @default.
- W115921675 hasPrimaryLocation W1159216751 @default.
- W115921675 hasRelatedWork W1487514163 @default.
- W115921675 hasRelatedWork W1554538771 @default.
- W115921675 hasRelatedWork W1701555181 @default.
- W115921675 hasRelatedWork W2017820330 @default.
- W115921675 hasRelatedWork W2053188030 @default.
- W115921675 hasRelatedWork W2105184212 @default.
- W115921675 hasRelatedWork W2116343261 @default.
- W115921675 hasRelatedWork W216527300 @default.
- W115921675 hasRelatedWork W2283990754 @default.
- W115921675 hasRelatedWork W2323715589 @default.
- W115921675 hasVolume "259" @default.
- W115921675 isParatext "false" @default.
- W115921675 isRetracted "false" @default.
- W115921675 magId "115921675" @default.
- W115921675 workType "article" @default.