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• W1159335004 startingPage "77" @default.
• W1159335004 abstract "The intercellular C-signal has a fundamental role in fruiting body morphogenesis in Myxococcus xanthus. In this chapter, our current understanding of how the C-signal acts at the molecular level to induce and coordinate events that are separated in time and space is discussed. The first evidence for intercellular signals important for fruiting body formation came from the isolation of a collection of mutants that displayed nonautonomous developmental defects. Importantly, aggregation, sporulation, and C-signal-dependent gene expression were induced earlier than in wild-type cells, whereas the rippling stage was completely skipped. Random transposon mutagenesis followed by screening for mutants with deficiencies in C-signal-dependent responses, isolation of extragenic suppressors of a csgA insertion mutant, proteomics, and biochemical analyses have been instrumental in the identification of proteins in this pathway. Several regulatory mechanisms help to restrict the activity of the pathway to starving cells. First, starvation induces the stringent response, which, in turn, induces csgA transcription and A-signal accumulation, which induces fruA transcription. Secondly, starvation induces mrpAB expression, and MrpAB induces mrpC transcription. Thirdly, by an unknown mechanism secretion of MXAN0206, the protease likely to cleave p25, is induced. Moreover, the establishment of cell-biology-based methods with green fluorescent protein (GFP) fusion proteins and immunofluorescence are likely to result in the detailed understanding of the spatial organization of M. xanthus cells during starvation." @default.
• W1159335004 created "2016-06-24" @default.
• W1159335004 creator A5074705819 @default.
• W1159335004 date "2014-04-09" @default.
• W1159335004 modified "2023-09-28" @default.
• W1159335004 title "Contact-Dependent Signaling in<i>Myxococcus xanthus</i>: the Function of the C-Signal in Fruiting Body Morphogenesis" @default.
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