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- W1159544006 abstract "Zerumbone, a sesquiterpene compound of edible ginger (Zingiber zerumbet), has been tested for its anti-EMT and anti-metastatic properties in TGF-β1-stimulated human lung cancer (A549) cells. Zerumbone (10/20 µM) treatment prior to TGF-β1-stimulation reversed the adverse morphological changes (fibroblastic-to-epithelial phenotype) and up-regulated the E-cadherin expression against TGF-β1-induced down-regulation. Immunofluorescence and luciferase activity data confirmed the up-regulated E-cadherin expression and transcriptional activity by zerumbone under TGF-β1-stimulation. Further evidence showed that zerumbone decreased TGF-β1-mediated phosphorylation and transcriptional activity of Smad2, but not Smad3. These results revealed that zerumbone inhibits the TGF-β-induced EMT via up-regulation of E-cadherin and down-regulation of Smad2 signalling pathways. Findings from wound-healing, invasion and colony formation experiments proved that zerumbone inhibits TGF-β1-mediated (metastatic) migration, invasion and anchorage-independent growth. Besides, zerumbone alone is capable of inducing autophagy and apoptosis in A549 cells. These results conclude that anti-EMT and anti-metastatic activities of zerumbone may contribute to the development of food-based chemopreventive drugs for non-small cell lung cancer treatment." @default.
- W1159544006 created "2016-06-24" @default.
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- W1159544006 date "2015-10-01" @default.
- W1159544006 modified "2023-10-18" @default.
- W1159544006 title "Zerumbone attenuates TGF-β1-mediated epithelial–mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signalling pathways in non-small cell lung cancer (A549) cells" @default.
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- W1159544006 doi "https://doi.org/10.1016/j.jff.2015.06.058" @default.
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