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- W1159598077 abstract "Fibroblast growth factor receptors (FGFRs) and FGF ligands are highly expressed in the developing kidney and lower urinary tract. Several classic studies showed many effects of exogenous FGF ligands on embryonic renal tissues in vitro and in vivo. Another older landmark publication showed that mice with a dominant negative Fgfr fragment had severe renal dysplasia. Together, these studies revealed the importance of FGFR signaling in kidney and lower urinary tract development. With the advent of modern gene targeting techniques, including conditional knockout approaches, several publications have revealed critical roles for FGFR signaling in many lineages of the kidney and lower urinary tract at different stages of development. FGFR signaling has been shown to be critical for early metanephric mesenchymal patterning, Wolffian duct patterning including induction of the ureteric bud, ureteric bud branching morphogenesis, nephron progenitor survival and nephrogenesis, and bladder mesenchyme patterning. FGFRs pattern these tissues by interacting with many other growth factor signaling pathways. Moreover, the many genetic Fgfr and Fgf animal models have structural defects mimicking numerous congenital anomalies of the kidney and urinary tract seen in humans. Finally, many studies have shown how FGFR signaling is critical for kidney and lower urinary tract patterning in humans." @default.
- W1159598077 created "2016-06-24" @default.
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- W1159598077 date "2015-08-21" @default.
- W1159598077 modified "2023-09-30" @default.
- W1159598077 title "Fibroblast growth factor receptor signaling in kidney and lower urinary tract development" @default.
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- W1159598077 cites W1787248623 @default.
- W1159598077 cites W1950995033 @default.
- W1159598077 cites W1961962216 @default.
- W1159598077 cites W1963512164 @default.
- W1159598077 cites W1963968195 @default.
- W1159598077 cites W1964117903 @default.
- W1159598077 cites W1965785388 @default.
- W1159598077 cites W1968217129 @default.
- W1159598077 cites W1981066682 @default.
- W1159598077 cites W1984564573 @default.
- W1159598077 cites W1988476050 @default.
- W1159598077 cites W1993796364 @default.
- W1159598077 cites W1995492118 @default.
- W1159598077 cites W1997631325 @default.
- W1159598077 cites W1998546239 @default.
- W1159598077 cites W2005401841 @default.
- W1159598077 cites W2014275971 @default.
- W1159598077 cites W2014866628 @default.
- W1159598077 cites W2016325403 @default.
- W1159598077 cites W2019733034 @default.
- W1159598077 cites W2025503796 @default.
- W1159598077 cites W2025645490 @default.
- W1159598077 cites W2025886884 @default.
- W1159598077 cites W2026527439 @default.
- W1159598077 cites W2036504666 @default.
- W1159598077 cites W2039431980 @default.
- W1159598077 cites W2043840480 @default.
- W1159598077 cites W2047727235 @default.
- W1159598077 cites W2048630443 @default.
- W1159598077 cites W2058528119 @default.
- W1159598077 cites W2059226469 @default.
- W1159598077 cites W2061628657 @default.
- W1159598077 cites W2063936800 @default.
- W1159598077 cites W2065338484 @default.
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- W1159598077 cites W2097090948 @default.
- W1159598077 cites W2098604249 @default.
- W1159598077 cites W2102636621 @default.
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- W1159598077 doi "https://doi.org/10.1007/s00467-015-3151-1" @default.
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