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• W115963311 abstract "The major roles of glutathione (GSH) and glutathione S-transferases (GSTs) in the detoxification of xenobiotics predicts their important role in drug resistance. As such, both GSH and GSTs have been manipulated as targets in the design of novel chemotherapeutic drugs. The discovery that GSTs have additional roles in the cell as regulatory molecules in the mitogen-activated protein kinase pathways together with the more recent discovery of GSH as a regulatory posttranslational modification lend further weight to their already important roles in the anticancer drug resistance response. These findings highlight the importance of these targets in the creation of future novel anticancer drugs. This chapter gives a brief overview of the importance of both GSH and GST in the response to anticancer drug resistance, and highlights some of the anticancer drugs currently being investigated at various stages in the process from lab to clinic." @default.
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• W115963311 date "2007-11-08" @default.
• W115963311 modified "2023-10-18" @default.
• W115963311 title "Glutathione and Glutathione S-Transferases in Drug Resistance" @default.
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• W115963311 doi "https://doi.org/10.1007/978-1-59745-035-5_12" @default.
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