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- W115969946 abstract "Publisher Summary This chapter discusses the significance of the various forms of estrogen binding sites. Estrogen receptors are macromolecules that bind estrogen to form receptor hormone complexes. These complexes are generally involved with the stimulation of cellular growth and metabolism. This concept of steroid hormone action is widely known. Saturation analysis of uterine cytosol over a wide range of [ 3 H] estradiol concentrations reveals a curve for specifically bound [ 3 H] estradiol. Two types of macro molecule exist that bind estrogen in a stereospecific fashion: (1) type I, which has the properties of the classical cytosol estrogen receptor, and (2) type II, which has a lower affinity and a higher capacity for estradiol than type I. Type II sites also differ from type I as they do not undergo translocation from the cytoplasm to the nucleus after an estrogen injection. The implications of the existence of type II sites are far-reaching. Their presence interferes with the measurement of type I sites, producing an overestimate of type I and an incorrect identification of type II as type I." @default.
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- W115969946 date "1980-01-01" @default.
- W115969946 modified "2023-09-24" @default.
- W115969946 title "Heterogeneity of Estrogen Binding Sites: Relationship to Estrogen Receptors and Estrogen Responses" @default.
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- W115969946 doi "https://doi.org/10.1016/b978-0-12-571136-4.50009-7" @default.
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