FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W115983402> ?p ?o ?g. }

• W115983402 endingPage "279" @default.
• W115983402 startingPage "248" @default.
• W115983402 abstract "Investigations of animal models with diseases found in humans are important to the understanding of their pathophysiology and for developing new treatments. Both naturally occurring and genetically-manipulated animal models of human retinal and optic nerve diseases have been studied in this manner. Electroretinography (ERG) is valuable for the evaluation of the visual function of animal models, because a layer-by-layer assessment of the retina can be done objectively. We used ERGs to analyze the visual functions of animal models of human retinal and and optic nerve diseases. To investigate the contribution of the cone ON- and OFF-pathways to the mouse photopic ERGs, we studied the properties of the photopic ERGs of metabotropic glutamate receptor subtype 6-deficient mice. The results of the ERG and the effect of an intravitreous injection of cis-2,3 piperidine dicarboxylic acid (PDA) in these mice suggest that the contribution of the post-synaptic ON-pathway to the photopic ERG of mice is larger than that of the OFF-pathway. The ERGs of pikachurin-deficient mice had normal a-waves with severely delayed b-waves, indicating that the signal transmission from the photoreceptors to the bipolar cells was impaired in these mutant mice. We also generated a rabbit model of retinitis pigmentosa (RP), the rhodopsin P347L transgenic (Tg) rabbit, by using bacterial artificial chromosome (BAC) transgenesis. These rabbits showed a rod-dominant, progressive retinal degeneration with marked regional variations in the loss of photoreceptors. All ERG components of the Tg rabbits decreased progressively with the a-waves more affected than the b-waves, and with the oscillatory potentials (OPs) the best preserved. Interestingly, the OP amplitudes of young Tg rabbits were significantly larger than those of wild-type rabbits. Pharmacological experiments showed that the significantly larger OPs in young Tg rabbits resulted from secondary alterations in the inner retinal function. This type of supernormal OPs has also been observed in the focal macular ERGs of some RP patients. We succeeded also in eliciting focal photopic negative responses (PhNRs) from the macula of rhesus monkeys with a red stimulus spot on a blue background illumination. The amplitudes of the focal macular PhNRs were relatively large when compared to those of the a- and b-waves. We found that the PhNR of the upper macular area was significantly larger than that of the lower macula, and the PhNR of the nasal macula was significantly larger than that of the temporal macula. Results of intravitreal injection of tetrodotoxin(TTX) in monkeys suggest that these asymmetries of PhNR are mainly caused by TTX-sensitive spiking neurons of the inner retina. Thus, ERGs have proven to be quite useful for objectively studying the visual functions in various animal models of human retinal and optic nerve diseases." @default.
• W115983402 created "2016-06-24" @default.
• W115983402 creator A5039865170 @default.
• W115983402 date "2010-03-01" @default.
• W115983402 modified "2023-09-26" @default.
• W115983402 title "Animal models of human retinal and optic nerve diseases analysed using electroretinography" @default.
• W115983402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20387538" @default.
• W115983402 hasPublicationYear "2010" @default.
• W115983402 type Work @default.
• W115983402 sameAs 115983402 @default.
• W115983402 citedByCount "2" @default.
• W115983402 countsByYear W1159834022016 @default.
• W115983402 countsByYear W1159834022023 @default.
• W115983402 crossrefType "journal-article" @default.
• W115983402 hasAuthorship W115983402A5039865170 @default.
• W115983402 hasConcept C103796816 @default.
• W115983402 hasConcept C118487528 @default.
• W115983402 hasConcept C169760540 @default.
• W115983402 hasConcept C196843134 @default.
• W115983402 hasConcept C2777093970 @default.
• W115983402 hasConcept C2779113765 @default.
• W115983402 hasConcept C2780827179 @default.
• W115983402 hasConcept C2780837183 @default.
• W115983402 hasConcept C2781040256 @default.
• W115983402 hasConcept C2781114197 @default.
• W115983402 hasConcept C519853106 @default.
• W115983402 hasConcept C54497739 @default.
• W115983402 hasConcept C71924100 @default.
• W115983402 hasConcept C7243750 @default.
• W115983402 hasConcept C73247094 @default.
• W115983402 hasConcept C86803240 @default.
• W115983402 hasConcept C87073359 @default.
• W115983402 hasConcept C95444343 @default.
• W115983402 hasConceptScore W115983402C103796816 @default.
• W115983402 hasConceptScore W115983402C118487528 @default.
• W115983402 hasConceptScore W115983402C169760540 @default.
• W115983402 hasConceptScore W115983402C196843134 @default.
• W115983402 hasConceptScore W115983402C2777093970 @default.
• W115983402 hasConceptScore W115983402C2779113765 @default.
• W115983402 hasConceptScore W115983402C2780827179 @default.
• W115983402 hasConceptScore W115983402C2780837183 @default.
• W115983402 hasConceptScore W115983402C2781040256 @default.
• W115983402 hasConceptScore W115983402C2781114197 @default.
• W115983402 hasConceptScore W115983402C519853106 @default.
• W115983402 hasConceptScore W115983402C54497739 @default.
• W115983402 hasConceptScore W115983402C71924100 @default.
• W115983402 hasConceptScore W115983402C7243750 @default.
• W115983402 hasConceptScore W115983402C73247094 @default.
• W115983402 hasConceptScore W115983402C86803240 @default.
• W115983402 hasConceptScore W115983402C87073359 @default.
• W115983402 hasConceptScore W115983402C95444343 @default.
• W115983402 hasIssue "3" @default.
• W115983402 hasLocation W1159834021 @default.
• W115983402 hasLocation W1159834022 @default.
• W115983402 hasOpenAccess W115983402 @default.
• W115983402 hasPrimaryLocation W1159834021 @default.
• W115983402 hasRelatedWork W108344685 @default.
• W115983402 hasRelatedWork W148070368 @default.
• W115983402 hasRelatedWork W1542711346 @default.
• W115983402 hasRelatedWork W1815230278 @default.
• W115983402 hasRelatedWork W1934437721 @default.
• W115983402 hasRelatedWork W1963651026 @default.
• W115983402 hasRelatedWork W1971353549 @default.
• W115983402 hasRelatedWork W1991585300 @default.
• W115983402 hasRelatedWork W2002763673 @default.
• W115983402 hasRelatedWork W2005474543 @default.
• W115983402 hasRelatedWork W2025988461 @default.
• W115983402 hasRelatedWork W2028937107 @default.
• W115983402 hasRelatedWork W2048953595 @default.
• W115983402 hasRelatedWork W2074715006 @default.
• W115983402 hasRelatedWork W2091598235 @default.
• W115983402 hasRelatedWork W2164982332 @default.
• W115983402 hasRelatedWork W2298862102 @default.
• W115983402 hasRelatedWork W2488075321 @default.
• W115983402 hasRelatedWork W2594895413 @default.
• W115983402 hasRelatedWork W3095493014 @default.
• W115983402 hasVolume "114" @default.
• W115983402 isParatext "false" @default.
• W115983402 isRetracted "false" @default.
• W115983402 magId "115983402" @default.
• W115983402 workType "article" @default.