FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W115989438> ?p ?o ?g. }

• W115989438 endingPage "H18" @default.
• W115989438 startingPage "H9" @default.
• W115989438 abstract "The isometric force-frequency relationship of isolated rat ventricular trabeculae (diameter <250 μm) was examined at 24, 30, and 37°C at stimulation frequencies (0.1–12 Hz) encompassing the physiological range. Some muscles were microinjected with fura PE3 to monitor the diastolic and systolic intracellular concentration of Ca 2+ ([Ca 2+ ] i ). At a near-physiological external Ca 2+ concentration ([Ca 2+ ] o ) of 1 mM, a positive force-frequency relationship was demonstrated at all temperatures. The force-frequency relationship became negative at high frequencies (e.g., >6 Hz at 30°C) at 1 mM [Ca 2+ ] o or at low frequencies at 8 mM [Ca 2+ ] o . The twitch and Ca 2+ transient became shorter as stimulation frequency increased; these changes were related to changes in systolic, rather than diastolic, [Ca 2+ ] i and were not blocked by inhibitors of Ca 2+ /calmodulin-dependent protein kinase II. The positive force-frequency relationship of rat trabeculae was caused by a frequency-dependent loading of the sarcoplasmic reticulum (SR) with Ca 2+ . We suggest that at high frequencies, or under conditions of Ca 2+ overload, this loading saturates. Processes that tend to decrease SR Ca 2+ release will then predominate, resulting in a negative force-frequency relationship." @default.
• W115989438 created "2016-06-24" @default.
• W115989438 creator A5044154302 @default.
• W115989438 creator A5080971931 @default.
• W115989438 date "1999-01-01" @default.
• W115989438 modified "2023-09-27" @default.
• W115989438 title "Positive force- and [Ca²⁺]_i-frequency relationships in rat ventricular trabeculae at physiological frequencies" @default.
• W115989438 cites W132504932 @default.
• W115989438 cites W1963851776 @default.
• W115989438 cites W1972134881 @default.
• W115989438 cites W2005865511 @default.
• W115989438 cites W2009300465 @default.
• W115989438 cites W2011038097 @default.
• W115989438 cites W2011456851 @default.
• W115989438 cites W2023587889 @default.
• W115989438 cites W2031359510 @default.
• W115989438 cites W2036987821 @default.
• W115989438 cites W2037633314 @default.
• W115989438 cites W2042681520 @default.
• W115989438 cites W2053316039 @default.
• W115989438 cites W2055301846 @default.
• W115989438 cites W2061187992 @default.
• W115989438 cites W2069198907 @default.
• W115989438 cites W2072339024 @default.
• W115989438 cites W2089412926 @default.
• W115989438 cites W2090135050 @default.
• W115989438 cites W2122689970 @default.
• W115989438 cites W2130513658 @default.
• W115989438 cites W2138945495 @default.
• W115989438 cites W2172519975 @default.
• W115989438 cites W2231651666 @default.
• W115989438 cites W2415909923 @default.
• W115989438 cites W2418817212 @default.
• W115989438 cites W2463799964 @default.
• W115989438 cites W2885090528 @default.
• W115989438 cites W56403793 @default.
• W115989438 doi "https://doi.org/10.1152/ajpheart.1999.276.1.h9" @default.
• W115989438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9887011" @default.
• W115989438 hasPublicationYear "1999" @default.
• W115989438 type Work @default.
• W115989438 sameAs 115989438 @default.
• W115989438 citedByCount "99" @default.
• W115989438 countsByYear W1159894382012 @default.
• W115989438 countsByYear W1159894382013 @default.
• W115989438 countsByYear W1159894382014 @default.
• W115989438 countsByYear W1159894382015 @default.
• W115989438 countsByYear W1159894382016 @default.
• W115989438 countsByYear W1159894382017 @default.
• W115989438 countsByYear W1159894382018 @default.
• W115989438 countsByYear W1159894382019 @default.
• W115989438 countsByYear W1159894382020 @default.
• W115989438 countsByYear W1159894382021 @default.
• W115989438 countsByYear W1159894382022 @default.
• W115989438 countsByYear W1159894382023 @default.
• W115989438 crossrefType "journal-article" @default.
• W115989438 hasAuthorship W115989438A5044154302 @default.
• W115989438 hasAuthorship W115989438A5080971931 @default.
• W115989438 hasBestOaLocation W1159894381 @default.
• W115989438 hasConcept C103486182 @default.
• W115989438 hasConcept C12554922 @default.
• W115989438 hasConcept C126322002 @default.
• W115989438 hasConcept C134018914 @default.
• W115989438 hasConcept C158617107 @default.
• W115989438 hasConcept C178790620 @default.
• W115989438 hasConcept C185592680 @default.
• W115989438 hasConcept C24998067 @default.
• W115989438 hasConcept C29688787 @default.
• W115989438 hasConcept C519063684 @default.
• W115989438 hasConcept C55493867 @default.
• W115989438 hasConcept C57900726 @default.
• W115989438 hasConcept C71924100 @default.
• W115989438 hasConcept C84393581 @default.
• W115989438 hasConcept C86803240 @default.
• W115989438 hasConceptScore W115989438C103486182 @default.
• W115989438 hasConceptScore W115989438C12554922 @default.
• W115989438 hasConceptScore W115989438C126322002 @default.
• W115989438 hasConceptScore W115989438C134018914 @default.
• W115989438 hasConceptScore W115989438C158617107 @default.
• W115989438 hasConceptScore W115989438C178790620 @default.
• W115989438 hasConceptScore W115989438C185592680 @default.
• W115989438 hasConceptScore W115989438C24998067 @default.
• W115989438 hasConceptScore W115989438C29688787 @default.
• W115989438 hasConceptScore W115989438C519063684 @default.
• W115989438 hasConceptScore W115989438C55493867 @default.
• W115989438 hasConceptScore W115989438C57900726 @default.
• W115989438 hasConceptScore W115989438C71924100 @default.
• W115989438 hasConceptScore W115989438C84393581 @default.
• W115989438 hasConceptScore W115989438C86803240 @default.
• W115989438 hasIssue "1" @default.
• W115989438 hasLocation W1159894381 @default.
• W115989438 hasLocation W1159894382 @default.
• W115989438 hasOpenAccess W115989438 @default.
• W115989438 hasPrimaryLocation W1159894381 @default.
• W115989438 hasRelatedWork W1984619393 @default.
• W115989438 hasRelatedWork W2003842308 @default.
• W115989438 hasRelatedWork W2034768996 @default.
• W115989438 hasRelatedWork W2046401998 @default.
• W115989438 hasRelatedWork W2054992011 @default.

• next