FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1159905982> ?p ?o ?g. }

• W1159905982 endingPage "e0130565" @default.
• W1159905982 startingPage "e0130565" @default.
• W1159905982 abstract "Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Identifying mechanisms of PCa dormancy and reactivation remain a challenge partly due to the lack of in vitro models. Here, we characterized in vitro PCa dormancy-reactivation by inducing cells from three patient-derived xenograft (PDX) lines to proliferate through tumor cell contact with each other and with bone marrow stroma. Proliferating PCa cells demonstrated tumor cell-cell contact and integrin clustering by immunofluorescence. Global gene expression analyses on proliferating cells cultured on bone marrow stroma revealed a downregulation of TGFB2 in all of the three proliferating PCa PDX lines when compared to their non-proliferating counterparts. Furthermore, constitutive activation of myosin light chain kinase (MLCK), a downstream effector of integrin-beta1 and TGF-beta2, in non-proliferating cells promoted cell proliferation. This cell proliferation was associated with an upregulation of CDK6 and a downregulation of E2F4. Taken together, our data provide the first clinically relevant in vitro model to support cellular adhesion and downregulation of TGFB2 as a potential mechanism by which PCa cells may escape from dormancy. Targeting the TGF-beta2-associated mechanism could provide novel opportunities to prevent lethal PCa metastasis." @default.
• W1159905982 created "2016-06-24" @default.
• W1159905982 creator A5002466627 @default.
• W1159905982 creator A5014047283 @default.
• W1159905982 creator A5017098435 @default.
• W1159905982 creator A5018745405 @default.
• W1159905982 creator A5021235635 @default.
• W1159905982 creator A5039685317 @default.
• W1159905982 creator A5047140847 @default.
• W1159905982 creator A5050639318 @default.
• W1159905982 creator A5057037633 @default.
• W1159905982 creator A5064176877 @default.
• W1159905982 creator A5067800417 @default.
• W1159905982 creator A5077753752 @default.
• W1159905982 creator A5079338108 @default.
• W1159905982 creator A5088583553 @default.
• W1159905982 date "2015-06-19" @default.
• W1159905982 modified "2023-10-18" @default.
• W1159905982 title "Cellular Adhesion Promotes Prostate Cancer Cells Escape from Dormancy" @default.
• W1159905982 cites W1230611947 @default.
• W1159905982 cites W130428498 @default.
• W1159905982 cites W1972982796 @default.
• W1159905982 cites W1973814270 @default.
• W1159905982 cites W1976655304 @default.
• W1159905982 cites W1979983857 @default.
• W1159905982 cites W2005302422 @default.
• W1159905982 cites W2007876874 @default.
• W1159905982 cites W2009302881 @default.
• W1159905982 cites W2013955439 @default.
• W1159905982 cites W2015228508 @default.
• W1159905982 cites W2026470201 @default.
• W1159905982 cites W2031737454 @default.
• W1159905982 cites W2036453287 @default.
• W1159905982 cites W2037133813 @default.
• W1159905982 cites W2039430052 @default.
• W1159905982 cites W2040196938 @default.
• W1159905982 cites W2040916923 @default.
• W1159905982 cites W2049058992 @default.
• W1159905982 cites W2054779757 @default.
• W1159905982 cites W2060313943 @default.
• W1159905982 cites W2060771458 @default.
• W1159905982 cites W2074202485 @default.
• W1159905982 cites W2082276924 @default.
• W1159905982 cites W2082867992 @default.
• W1159905982 cites W2083049240 @default.
• W1159905982 cites W2090230770 @default.
• W1159905982 cites W2092906344 @default.
• W1159905982 cites W2093788375 @default.
• W1159905982 cites W2096800294 @default.
• W1159905982 cites W2101297848 @default.
• W1159905982 cites W2101335366 @default.
• W1159905982 cites W2101446068 @default.
• W1159905982 cites W2106263242 @default.
• W1159905982 cites W2115900736 @default.
• W1159905982 cites W2118375252 @default.
• W1159905982 cites W2120392231 @default.
• W1159905982 cites W2124653487 @default.
• W1159905982 cites W2127611014 @default.
• W1159905982 cites W2134391588 @default.
• W1159905982 cites W2138231208 @default.
• W1159905982 cites W2152054207 @default.
• W1159905982 cites W2155258698 @default.
• W1159905982 cites W2156179633 @default.
• W1159905982 cites W2156581417 @default.
• W1159905982 cites W2163472474 @default.
• W1159905982 cites W2165022280 @default.
• W1159905982 cites W2171774285 @default.
• W1159905982 cites W4213141530 @default.
• W1159905982 cites W4294107304 @default.
• W1159905982 doi "https://doi.org/10.1371/journal.pone.0130565" @default.
• W1159905982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4475050" @default.
• W1159905982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26090669" @default.
• W1159905982 hasPublicationYear "2015" @default.
• W1159905982 type Work @default.
• W1159905982 sameAs 1159905982 @default.
• W1159905982 citedByCount "46" @default.
• W1159905982 countsByYear W11599059822015 @default.
• W1159905982 countsByYear W11599059822016 @default.
• W1159905982 countsByYear W11599059822017 @default.
• W1159905982 countsByYear W11599059822018 @default.
• W1159905982 countsByYear W11599059822019 @default.
• W1159905982 countsByYear W11599059822020 @default.
• W1159905982 countsByYear W11599059822021 @default.
• W1159905982 countsByYear W11599059822022 @default.
• W1159905982 countsByYear W11599059822023 @default.
• W1159905982 crossrefType "journal-article" @default.
• W1159905982 hasAuthorship W1159905982A5002466627 @default.
• W1159905982 hasAuthorship W1159905982A5014047283 @default.
• W1159905982 hasAuthorship W1159905982A5017098435 @default.
• W1159905982 hasAuthorship W1159905982A5018745405 @default.
• W1159905982 hasAuthorship W1159905982A5021235635 @default.
• W1159905982 hasAuthorship W1159905982A5039685317 @default.
• W1159905982 hasAuthorship W1159905982A5047140847 @default.
• W1159905982 hasAuthorship W1159905982A5050639318 @default.
• W1159905982 hasAuthorship W1159905982A5057037633 @default.
• W1159905982 hasAuthorship W1159905982A5064176877 @default.
• W1159905982 hasAuthorship W1159905982A5067800417 @default.
• W1159905982 hasAuthorship W1159905982A5077753752 @default.

• next