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• W115996514 abstract "Protective immunity against encapsulated bacteria can be achieved by eliciting serum antibodies directed against the polysaccharide capsule (Schneerson et al. 1971; Kaijser and Ahlstedt 1977; Egan et al. 1983). In adults and in children over the age of 2 years this can readily be accomplished by the use of polysaccharide vaccines (Makela et al. 1977; Parke et al. 1977; Makela et al. 1980; Vodopija et al. 1983). Infants, however, are unresponsive to most polysaccharide antigens (Smith etal. 1973; Parke et al. 1977; Peltola etal. 1977; Pincus et al. 1982; Kayhty et al. 1984), and a significant proportion of invasive and other serious bacterial infections caused by organisms such as Haemophilus influenzae type b (Hib; Kayhty et al. 1984), Neisseriae meningitidis groups A, B, and C (Band et al. 1983) and Streptococcus pneumoniae (Makela et al. 1980; Douglas and Miles 1984) occurs in this age group. Stimulation of antipolysaccharide antibodies in infants would be enormously important both from the medical point of view and from the inferences that can be drawn regarding our understanding of the mechanisms of neonatal unresponsiveness." @default.
• W115996514 created "2016-06-24" @default.
• W115996514 creator A5071692896 @default.
• W115996514 date "1985-01-01" @default.
• W115996514 modified "2023-09-25" @default.
• W115996514 title "Network Regulation of the Immune Response to Bacterial Polysaccharide Antigens" @default.
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• W115996514 doi "https://doi.org/10.1007/978-3-642-70675-2_5" @default.
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• W115996514 hasPublicationYear "1985" @default.
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