FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1160431330> ?p ?o ?g. }

• W1160431330 endingPage "2364" @default.
• W1160431330 startingPage "2351" @default.
• W1160431330 abstract "Peptide lipidation has proven to be an inexpensive and effective strategy for designing next-generation peptide-based drug compounds. In this study, the effect of the acyl chain length of ultrashort LiPs (CX-KYR-NH2; X=10, 12, 14 and 16) on their bacterial killing and membrane disruption kinetics was investigated. The geometric mean of the minimum inhibitory concentration (MIC) values for 4 pathogenic bacterial strains was 25 μM, with a selectivity index of 10.24 for C14-KYR-NH2. LiPs at all concentrations exhibited no cytotoxicity towards human erythrocytes, but towards Vero cells at 80 μM. All the LiPs adopted secondary structure in a membrane mimicking environment. C14-KYR-NH2 aggregated above 256 μM, while C16-KYR-NH2 did above 80 μM. All LiPs showed outer membrane permeabilization within 3 min after treatment, yet the extent and kinetics of inner membrane penetration and depolarization were dependent on the acyl chain length. Cell death subsequently occurred within 10 min, and killing activity appeared to correlate most with depolarization activity but not with outer or inner membrane permeability. AFM imaging of cells treated with C14-KYR-NH2 revealed rupture of the cell surface and cytosolic leakage depending on the length of incubation. This study highlights and follows the progression of events that occur during the membrane disintegration process over time, and determines the optimal amphipathicity of ultrashort LiPs with 12-14 carbon atoms for this membrane disrupting activity. The fast acting bactericidal properties of ultrashort LiPs with optimal chain lengths make them promising candidates for drug lead compounds." @default.
• W1160431330 created "2016-06-24" @default.
• W1160431330 creator A5008156428 @default.
• W1160431330 creator A5023272309 @default.
• W1160431330 creator A5039903015 @default.
• W1160431330 creator A5043390109 @default.
• W1160431330 creator A5068498787 @default.
• W1160431330 creator A5072700965 @default.
• W1160431330 creator A5075687160 @default.
• W1160431330 creator A5079347589 @default.
• W1160431330 date "2015-10-01" @default.
• W1160431330 modified "2023-10-04" @default.
• W1160431330 title "Effect of acyl chain length on therapeutic activity and mode of action of the CX-KYR-NH2 antimicrobial lipopeptide" @default.
• W1160431330 cites W1560177375 @default.
• W1160431330 cites W1966601618 @default.
• W1160431330 cites W1989270637 @default.
• W1160431330 cites W1999251604 @default.
• W1160431330 cites W1999621758 @default.
• W1160431330 cites W2000373952 @default.
• W1160431330 cites W2006490294 @default.
• W1160431330 cites W2006548740 @default.
• W1160431330 cites W2009941225 @default.
• W1160431330 cites W2010666335 @default.
• W1160431330 cites W2013588942 @default.
• W1160431330 cites W2015733198 @default.
• W1160431330 cites W2017968349 @default.
• W1160431330 cites W2020790969 @default.
• W1160431330 cites W2024650759 @default.
• W1160431330 cites W2025063713 @default.
• W1160431330 cites W2025938842 @default.
• W1160431330 cites W2029622368 @default.
• W1160431330 cites W2030460323 @default.
• W1160431330 cites W2031945883 @default.
• W1160431330 cites W2032546148 @default.
• W1160431330 cites W2036190802 @default.
• W1160431330 cites W2036860085 @default.
• W1160431330 cites W2052059366 @default.
• W1160431330 cites W2053579325 @default.
• W1160431330 cites W2057177907 @default.
• W1160431330 cites W2058831880 @default.
• W1160431330 cites W2063838098 @default.
• W1160431330 cites W2072792349 @default.
• W1160431330 cites W2080202466 @default.
• W1160431330 cites W2083835441 @default.
• W1160431330 cites W2088340422 @default.
• W1160431330 cites W2094262202 @default.
• W1160431330 cites W2096763392 @default.
• W1160431330 cites W2108246317 @default.
• W1160431330 cites W2115550568 @default.
• W1160431330 cites W2121496462 @default.
• W1160431330 cites W2127206088 @default.
• W1160431330 cites W2130444227 @default.
• W1160431330 cites W2141094946 @default.
• W1160431330 cites W2147993656 @default.
• W1160431330 cites W2148502464 @default.
• W1160431330 cites W2165482241 @default.
• W1160431330 cites W2169731524 @default.
• W1160431330 doi "https://doi.org/10.1016/j.bbamem.2015.07.004" @default.
• W1160431330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26170198" @default.
• W1160431330 hasPublicationYear "2015" @default.
• W1160431330 type Work @default.
• W1160431330 sameAs 1160431330 @default.
• W1160431330 citedByCount "31" @default.
• W1160431330 countsByYear W11604313302016 @default.
• W1160431330 countsByYear W11604313302017 @default.
• W1160431330 countsByYear W11604313302018 @default.
• W1160431330 countsByYear W11604313302019 @default.
• W1160431330 countsByYear W11604313302020 @default.
• W1160431330 countsByYear W11604313302021 @default.
• W1160431330 countsByYear W11604313302022 @default.
• W1160431330 countsByYear W11604313302023 @default.
• W1160431330 crossrefType "journal-article" @default.
• W1160431330 hasAuthorship W1160431330A5008156428 @default.
• W1160431330 hasAuthorship W1160431330A5023272309 @default.
• W1160431330 hasAuthorship W1160431330A5039903015 @default.
• W1160431330 hasAuthorship W1160431330A5043390109 @default.
• W1160431330 hasAuthorship W1160431330A5068498787 @default.
• W1160431330 hasAuthorship W1160431330A5072700965 @default.
• W1160431330 hasAuthorship W1160431330A5075687160 @default.
• W1160431330 hasAuthorship W1160431330A5079347589 @default.
• W1160431330 hasBestOaLocation W11604313301 @default.
• W1160431330 hasConcept C104317684 @default.
• W1160431330 hasConcept C121332964 @default.
• W1160431330 hasConcept C12554922 @default.
• W1160431330 hasConcept C127413603 @default.
• W1160431330 hasConcept C146587185 @default.
• W1160431330 hasConcept C148898269 @default.
• W1160431330 hasConcept C176947019 @default.
• W1160431330 hasConcept C185592680 @default.
• W1160431330 hasConcept C202751555 @default.
• W1160431330 hasConcept C2777425210 @default.
• W1160431330 hasConcept C2778106830 @default.
• W1160431330 hasConcept C2779281246 @default.
• W1160431330 hasConcept C2992270614 @default.
• W1160431330 hasConcept C4141045 @default.
• W1160431330 hasConcept C41625074 @default.
• W1160431330 hasConcept C42475967 @default.
• W1160431330 hasConcept C523546767 @default.

• next