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• W1161125749 endingPage "473" @default.
• W1161125749 startingPage "465" @default.
• W1161125749 abstract "Neutrophils form the first line of host defense against infections that combat pathogens using two major mechanisms, the phagocytosis or the release of neutrophil extracellular traps (NETs). The netosis (NET formation) exerts additional, unfavorable effects on the fitness of host cells and is also involved at the sites of lung infection, increasing the mucus viscosity and in the circulatory system where it can influence the intravascular clot formation. Although molecular mechanisms underlying the netosis are still incompletely understood, a role of NADPH oxidase that activates the production of reactive oxygen species (ROS) during the initiation of NETs has been well documented. Since several commonly used drugs can affects the netosis, our current study was aimed to determine the effects of selected mucolytic, anti-inflammatory and cardiovascular drugs on NET formation, with a special emphasis on ROS production and NADPH oxidase activity. The treatment of neutrophils with N-acetylcysteine, ketoprofen and ethamsylate reduced the production of ROS by these cells in a dose-dependent manner. NET formation was also modulated by selected drugs. N-acetylcysteine inhibited the netosis but in the presence of H2O2 this neutrophil ability was restored, indicating that N-acetylcysteine may influence the NET formation by modulating ROS productivity. The administration of ethamsylate led to a significant reduction in NET formation and this effect was not restored by H2O2 or S. aureus, suggesting the unexpected additional side effects of this drug. Ketoprofen seemed to promote ROS-independent NET release, simultaneously inhibiting ROS production. The results, obtained in this study strongly suggest that the therapeutic strategies applied in many neutrophil-mediated diseases should take into account the NET-associated effects." @default.
• W1161125749 created "2016-06-24" @default.
• W1161125749 creator A5010290287 @default.
• W1161125749 creator A5020083442 @default.
• W1161125749 creator A5055945625 @default.
• W1161125749 date "2015-01-01" @default.
• W1161125749 modified "2023-10-17" @default.
• W1161125749 title "Selected mucolytic, anti-inflammatory and cardiovascular drugs change the ability of neutrophils to form extracellular traps (NETs)" @default.
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• W1161125749 doi "https://doi.org/10.18388/abp.2015_1055" @default.
• W1161125749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26291043" @default.
• W1161125749 hasPublicationYear "2015" @default.
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