Matches in SemOpenAlex for { <https://semopenalex.org/work/W1161809969> ?p ?o ?g. }
- W1161809969 endingPage "7380" @default.
- W1161809969 startingPage "7371" @default.
- W1161809969 abstract "Mushrooms are a source of dietary fiber (DF) with a cholesterol-lowering effect. However, their underlying mechanisms are poorly understood. The effect of DF-enriched fractions from three mushrooms species on cholesterol-related expression was studied in vitro. The Pleurotus ostreatus DF fraction (PDF) was used in mice models to assess its potential palliative or preventive effect against hypercholesterolemia. PDF induced a transcriptional response in Caco-2 cells, suggesting a possible cholesterol-lowering effect. In the palliative setting, PDF reduced hepatic triglyceride likely because Dgat1 was downregulated. However, cholesterol-related biochemical data showed no changes and no relation with the observed transcriptional modulation. In the preventive setting, PDF modulated cholesterol-related genes expression in a manner similar to that of simvastatin and ezetimibe in the liver, although no changes in plasma and liver biochemical data were induced. Therefore, PDF may be useful reducing hepatic triglyceride accumulation. Because it induced a molecular response similar to hypocholesterolemic drugs in liver, further dose-dependent studies should be carried out." @default.
- W1161809969 created "2016-06-24" @default.
- W1161809969 creator A5002796700 @default.
- W1161809969 creator A5023685149 @default.
- W1161809969 creator A5025416815 @default.
- W1161809969 creator A5045920934 @default.
- W1161809969 creator A5054388312 @default.
- W1161809969 creator A5066250439 @default.
- W1161809969 creator A5066998219 @default.
- W1161809969 creator A5075492985 @default.
- W1161809969 creator A5077608525 @default.
- W1161809969 date "2015-08-18" @default.
- W1161809969 modified "2023-10-14" @default.
- W1161809969 title "Modulation of Cholesterol-Related Gene Expression by Dietary Fiber Fractions from Edible Mushrooms" @default.
- W1161809969 cites W1577577364 @default.
- W1161809969 cites W1838994941 @default.
- W1161809969 cites W1966922165 @default.
- W1161809969 cites W1975116875 @default.
- W1161809969 cites W1977420189 @default.
- W1161809969 cites W1979294030 @default.
- W1161809969 cites W1979648082 @default.
- W1161809969 cites W1979893339 @default.
- W1161809969 cites W1986682418 @default.
- W1161809969 cites W1990411609 @default.
- W1161809969 cites W1996535821 @default.
- W1161809969 cites W1997061472 @default.
- W1161809969 cites W2009632077 @default.
- W1161809969 cites W2013912802 @default.
- W1161809969 cites W2015805615 @default.
- W1161809969 cites W2018564581 @default.
- W1161809969 cites W2019703065 @default.
- W1161809969 cites W2020140378 @default.
- W1161809969 cites W2020369858 @default.
- W1161809969 cites W2023121536 @default.
- W1161809969 cites W2027663543 @default.
- W1161809969 cites W2028829090 @default.
- W1161809969 cites W2029073240 @default.
- W1161809969 cites W2030903401 @default.
- W1161809969 cites W2045223517 @default.
- W1161809969 cites W2065689560 @default.
- W1161809969 cites W2066301876 @default.
- W1161809969 cites W2078112527 @default.
- W1161809969 cites W2085323268 @default.
- W1161809969 cites W2086432724 @default.
- W1161809969 cites W2086487313 @default.
- W1161809969 cites W2087350056 @default.
- W1161809969 cites W2093678021 @default.
- W1161809969 cites W2105124027 @default.
- W1161809969 cites W2108031998 @default.
- W1161809969 cites W2108244474 @default.
- W1161809969 cites W2108571956 @default.
- W1161809969 cites W2114918609 @default.
- W1161809969 cites W2156504663 @default.
- W1161809969 cites W2158395120 @default.
- W1161809969 cites W2163284273 @default.
- W1161809969 cites W2163424622 @default.
- W1161809969 cites W2437934898 @default.
- W1161809969 cites W298171742 @default.
- W1161809969 cites W3031812472 @default.
- W1161809969 cites W4247935329 @default.
- W1161809969 doi "https://doi.org/10.1021/acs.jafc.5b02942" @default.
- W1161809969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26284928" @default.
- W1161809969 hasPublicationYear "2015" @default.
- W1161809969 type Work @default.
- W1161809969 sameAs 1161809969 @default.
- W1161809969 citedByCount "39" @default.
- W1161809969 countsByYear W11618099692016 @default.
- W1161809969 countsByYear W11618099692017 @default.
- W1161809969 countsByYear W11618099692018 @default.
- W1161809969 countsByYear W11618099692019 @default.
- W1161809969 countsByYear W11618099692020 @default.
- W1161809969 countsByYear W11618099692021 @default.
- W1161809969 countsByYear W11618099692022 @default.
- W1161809969 countsByYear W11618099692023 @default.
- W1161809969 crossrefType "journal-article" @default.
- W1161809969 hasAuthorship W1161809969A5002796700 @default.
- W1161809969 hasAuthorship W1161809969A5023685149 @default.
- W1161809969 hasAuthorship W1161809969A5025416815 @default.
- W1161809969 hasAuthorship W1161809969A5045920934 @default.
- W1161809969 hasAuthorship W1161809969A5054388312 @default.
- W1161809969 hasAuthorship W1161809969A5066250439 @default.
- W1161809969 hasAuthorship W1161809969A5066998219 @default.
- W1161809969 hasAuthorship W1161809969A5075492985 @default.
- W1161809969 hasAuthorship W1161809969A5077608525 @default.
- W1161809969 hasConcept C104317684 @default.
- W1161809969 hasConcept C126322002 @default.
- W1161809969 hasConcept C134018914 @default.
- W1161809969 hasConcept C150194340 @default.
- W1161809969 hasConcept C185592680 @default.
- W1161809969 hasConcept C202751555 @default.
- W1161809969 hasConcept C2776329913 @default.
- W1161809969 hasConcept C2776474821 @default.
- W1161809969 hasConcept C2778123023 @default.
- W1161809969 hasConcept C2778163477 @default.
- W1161809969 hasConcept C2778657065 @default.
- W1161809969 hasConcept C2778913445 @default.
- W1161809969 hasConcept C2780072125 @default.
- W1161809969 hasConcept C2780948078 @default.