Matches in SemOpenAlex for { <https://semopenalex.org/work/W116185893> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W116185893 endingPage "77" @default.
- W116185893 startingPage "72" @default.
- W116185893 abstract "The dried rhizomes of Astilbe thunbergii (Sieb. et Zucc) Miq (Saxifragaceae) have been traditionally used for the treatments of a sword cut, wound bitten by animals, frost-bite, burn, suppurative dermatitis or skin inflammatory diseases from the Tang period (about 8th century) in China. The physiological actions, especially the wound-healing effects of this drug are not yet well understood. In this study, we examined the effects of an ethanol extract of Astilbe thunbergii rhizomes on burn wound healing in mice. The topical application at a dose of 100 mg ointment per wound of 70% ethanol extract (0.5 or 1.0% (w/w) ointment) of this drug promoted the burn wound healing. The ethanol extract was divided into two fractions (ethyl acetate-soluble and -insoluble fractions), and it was found that the topical application at a dose of 100 mg ointment per wound of the ethyl acetate-soluble fraction (0.5 and 1.0% ointment) promoted the burn wound healing. Based on this finding, we attempted to isolate the active substance(s) from the ethyl acetate-soluble fraction. Three active substances 1, 2 and 3, were obtained from A. thunbergii rhizomes as promotional effectors of burn wound healing in mice. Based on the analysis of 1H and 13C NMR spectra, compounds 1, 2 and 3 were identified as eucryphin (1), bergenin (2) and astilbin (3), respectively. The effective dose (ED50) of compounds 1, 2 and 3 on burn wound healing were 4, 190 and 64 μg/wound, respectively. Among these three compounds, eucryphin (1) promoted the burn wound healing most strongly." @default.
- W116185893 created "2016-06-24" @default.
- W116185893 creator A5018525351 @default.
- W116185893 creator A5030209507 @default.
- W116185893 creator A5065800084 @default.
- W116185893 date "2007-01-01" @default.
- W116185893 modified "2023-10-01" @default.
- W116185893 title "Effects of Astilbe thunbergii rhizomes on wound healing" @default.
- W116185893 cites W1945433578 @default.
- W116185893 cites W1971248512 @default.
- W116185893 cites W1975114623 @default.
- W116185893 cites W1983763042 @default.
- W116185893 cites W1984186291 @default.
- W116185893 cites W1986340288 @default.
- W116185893 cites W2001808272 @default.
- W116185893 cites W2013284753 @default.
- W116185893 cites W2020719588 @default.
- W116185893 cites W2021877145 @default.
- W116185893 cites W2043863730 @default.
- W116185893 cites W2070806030 @default.
- W116185893 cites W2074618631 @default.
- W116185893 cites W2085789849 @default.
- W116185893 cites W2098089604 @default.
- W116185893 cites W2108145145 @default.
- W116185893 cites W2112937322 @default.
- W116185893 cites W2113422614 @default.
- W116185893 cites W2134520728 @default.
- W116185893 cites W2158640707 @default.
- W116185893 cites W2606369429 @default.
- W116185893 cites W4239643251 @default.
- W116185893 doi "https://doi.org/10.1016/j.jep.2006.07.007" @default.
- W116185893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16920297" @default.
- W116185893 hasPublicationYear "2007" @default.
- W116185893 type Work @default.
- W116185893 sameAs 116185893 @default.
- W116185893 citedByCount "35" @default.
- W116185893 countsByYear W1161858932012 @default.
- W116185893 countsByYear W1161858932013 @default.
- W116185893 countsByYear W1161858932014 @default.
- W116185893 countsByYear W1161858932015 @default.
- W116185893 countsByYear W1161858932016 @default.
- W116185893 countsByYear W1161858932017 @default.
- W116185893 countsByYear W1161858932020 @default.
- W116185893 countsByYear W1161858932021 @default.
- W116185893 countsByYear W1161858932022 @default.
- W116185893 countsByYear W1161858932023 @default.
- W116185893 crossrefType "journal-article" @default.
- W116185893 hasAuthorship W116185893A5018525351 @default.
- W116185893 hasAuthorship W116185893A5030209507 @default.
- W116185893 hasAuthorship W116185893A5065800084 @default.
- W116185893 hasConcept C134550120 @default.
- W116185893 hasConcept C141071460 @default.
- W116185893 hasConcept C185592680 @default.
- W116185893 hasConcept C2779858419 @default.
- W116185893 hasConcept C2780161600 @default.
- W116185893 hasConcept C2780269544 @default.
- W116185893 hasConcept C3019879682 @default.
- W116185893 hasConcept C55493867 @default.
- W116185893 hasConcept C556039675 @default.
- W116185893 hasConcept C71924100 @default.
- W116185893 hasConcept C98274493 @default.
- W116185893 hasConceptScore W116185893C134550120 @default.
- W116185893 hasConceptScore W116185893C141071460 @default.
- W116185893 hasConceptScore W116185893C185592680 @default.
- W116185893 hasConceptScore W116185893C2779858419 @default.
- W116185893 hasConceptScore W116185893C2780161600 @default.
- W116185893 hasConceptScore W116185893C2780269544 @default.
- W116185893 hasConceptScore W116185893C3019879682 @default.
- W116185893 hasConceptScore W116185893C55493867 @default.
- W116185893 hasConceptScore W116185893C556039675 @default.
- W116185893 hasConceptScore W116185893C71924100 @default.
- W116185893 hasConceptScore W116185893C98274493 @default.
- W116185893 hasIssue "1" @default.
- W116185893 hasLocation W1161858931 @default.
- W116185893 hasLocation W1161858932 @default.
- W116185893 hasOpenAccess W116185893 @default.
- W116185893 hasPrimaryLocation W1161858931 @default.
- W116185893 hasRelatedWork W116185893 @default.
- W116185893 hasRelatedWork W1529054384 @default.
- W116185893 hasRelatedWork W1920037450 @default.
- W116185893 hasRelatedWork W1984716135 @default.
- W116185893 hasRelatedWork W2079061322 @default.
- W116185893 hasRelatedWork W2554494221 @default.
- W116185893 hasRelatedWork W2611718861 @default.
- W116185893 hasRelatedWork W2748952813 @default.
- W116185893 hasRelatedWork W2899084033 @default.
- W116185893 hasRelatedWork W2981441584 @default.
- W116185893 hasVolume "109" @default.
- W116185893 isParatext "false" @default.
- W116185893 isRetracted "false" @default.
- W116185893 magId "116185893" @default.
- W116185893 workType "article" @default.