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- W11631600 abstract "AIM: To investigate the effects of proliferation and apoptosis induced by cyclooxygenase-2 (COX-2) inhibitor celecoxib in combination with cisplatin. METHODS: The human pancreatic cancer cell line BxPC-3 cells were treated with COX-2 inhibitors celecoxib and cisplatin. The cell relative viability was examined using 3 (4, 5-dimethylethiazoly 1-2-) 2, 5-diphonyl tetrazolium bromide (MTT) assays. the expression of COX-2 mRNA was detected by RT-PCR, flow cytometry and Hoechst-33258 were used to demonstrate apoptotic changes in celecoxib and cisplatin treated cells. RESULTS: After treatment of BxPC-3 cells with celecoxib, as measured by MTT, cell viability was inhibited in a dosedependent and time-dependent manner with an IC50 of 100 nM at the time of 24h. The expression of COX-2 mRNA could be significantly decreased by celecoxib. Furthermore, we demonstrated that the combination of celecoxib with cisplatin inhibited cell growth and induced cell apoptosis to a greater degree than either compound alone. The apoptotic morphologies were demonstrated by Hoechst-33 258. CONCLUSION: Combination of celecoxib with cisplatin inhibits cell proliferation and induces cell apoptosis, and the potent effectiveness of celecoxib in combination with gemcitabine may hold a promise in the clinical treatment of pancreatic cancer. Liu JW, Li KZ, Dou KF, Song ZS, Su MQ, Yu WB. Effects of COX-2 inhibitor with cisplatin on proliferation and apoptosis of pancreatic cancer cells. Shijie Huaren Xiaohua Zazhi 2004;12(5):1139-1143" @default.
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- W11631600 date "2004-01-01" @default.
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- W11631600 title "Effects of COX-2 inhibitor with cisplatin on proliferation and apoptosis of pancreatic cancer cells" @default.
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- W11631600 doi "https://doi.org/10.11569/wcjd.v12.i5.1139" @default.
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