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- W1163184503 abstract "textabstractThe function of airway smooth muscle in normal subjects is not evident. Possiblephysiological roles include maintenance of optimal regional ventilation/perfusionratios, reduction of anatomic dead space, stabilisation of cartilaginous bronchi,defense against impurities and, less likely, squeezing mucus out of mucous glandsand pulling open the alveoli next to the airways1. Any role of airway smoothmuscle is necessarily limited, because an important degree of contraction willlead to airway narrowing and to an increased work of breathing. There is, however,no doubt that in asthma the acute bronchoconstriction following exposure tononspecific or allergic stimuli is due to airway smooth muscle contraction. Mostresearch on airway smooth muscle function has therefore concentrated onclarifying its role in bronchial hyperresponsiveness, airway obstruction andallergy.From the foregoing chapters it can be concluded that many factors may beinvolved in the pathogenesis of the abnormal responsiveness of airway smoothmuscle in patients with asthma or chronic bronchitis. One of these factors isan intrinsic abnormality of the airway smooth muscle cells. In order to examinethis, several animal models have been developed, most of which have featuresin common with human allergic bronchoconstriction2• Because of importantdifferences between species, and because there is no satisfactory animal modelof spontaneous, non-allergic asthma, it is crucial to study human airway smoothmuscle from subjects with and without airway hyperresponsiveness. The researchon human lung tissue in vitro has been limited by the supply, and by difficultiesin obtaining stable and reproducible responses of airway smooth muscle in vitro.Moreover, it is very difficult to obtain lung tissue from asthmatic subjects.This chapter will give a summary of the research on airway smooth musclehyperresponsiveness in experimental animals and man. From these data, theaims of the studies to be presented in parts II and III will be derived and brieflyoutlined." @default.
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- W1163184503 date "1987-12-16" @default.
- W1163184503 modified "2023-09-24" @default.
- W1163184503 title "Human airway smooth muscle" @default.
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