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- W116324504 abstract "Several laboratories have shown that when rats are fasted, the amount of lipoprotein lipase (LPL) at the vascular endothelium in heart (monitored as the amount released by heparin) increases severalfold without corresponding changes in the production of LPL. This suggests that there is a change in endothelial binding of LPL. To study this, 125 I-labeled bovine LPL was injected. The fraction that bound in the heart was more than twice as high in fasted than in fed rats, 4.3% compared with 1.9% of the injected dose. Refeeding reversed this in 5 h. When unlabeled LPL was injected before the tracer, the fraction of 125 I-LPL that bound in heart decreased, indicating that the binding was saturable. When isolated hearts were perfused at 4°C with a single pass of labeled LPL, twice as much bound in hearts of fasted rats. We conclude that fasting causes a change in the vascular endothelium in heart such that its ability to bind LPL increases." @default.
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- W116324504 date "2000-02-01" @default.
- W116324504 modified "2023-10-14" @default.
- W116324504 title "Nutritional regulation of binding sites for lipoprotein lipase in rat heart" @default.
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- W116324504 doi "https://doi.org/10.1152/ajpendo.2000.278.2.e211" @default.
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