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- W1164273539 abstract "Hypothalamic diabetes insipidus (DI), also known as central, neurogenic, or hypothalamic DI, results from the decreased secretion of osmoregulated arginine vasopressin (AVP) hormone, which is synthesized in the perikarya of large neurosecretory cells located mainly in the supraoptic and paraventricular nuclei of the hypothalamus. This chapter discusses the data on auto-immune hypothalamic DI and the possible further research into auto-immune hypothalamitis. Autoimmunity may also play a role in other hypothalamic endocrine defects, which have hitherto been regarded as idiopathic. It is theoretically possible that some cases of corticotropin deficiency, hypothyroidism, hypogonadism, or growth hormone deficiency are related to cell type-specific hypothalamic autoimmunity. However, the inaccessability of hypothalamic tissue in vivo and the poor availability of fresh human postmortem hypothalamus, remain a major obstacle in further investigations. Animal models, such as the spontaneously diabetic nonobese (NOD) mouse, have provided new insights into the pathogenesis of auto-immune diseases and allow the development of new therapeutic strategies. The availability of new techniques, such as the screening of a human complementary DNA (cDNA) library with the autoantibodies, may allow proceeding in this field." @default.
- W1164273539 created "2016-06-24" @default.
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- W1164273539 date "1992-01-01" @default.
- W1164273539 modified "2023-09-23" @default.
- W1164273539 title "Chapter 20 Autoimmune hypothalamic diabetes insipidus (“autoimmune hypothalamitis”)" @default.
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- W1164273539 doi "https://doi.org/10.1016/s0079-6123(08)64579-3" @default.
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