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• W1165431427 abstract "Pancreatitis is the most common benign condition affecting the pancreas and it occurs in two forms acute and chronic characterized by different clinical, morphological and histological features (10). Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of pancreas leading to irreversible structural changes causing both endocrine and exocrine dysfunction. The hallmarks of CP include abdominal pain, malabsorption, malnutrition, diabetes and pancreatic calcification. Currently there is no effective medical treatment for treating this disease especially when it is recognized at a late stage. Early detection of this condition may prevent further progression of the disease process. Diagnosis and evaluation of CP can be quite challenging and usually needs a battery of tests. Endoscopic Retrograde CholangioPancreatography (ERCP) was earlier considered as the gold standard for the diagnosis for CP but today other modalities such as Ultrasonography (US), Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Endoscopic ultrasound (EUS) are used to evaluate the structural changes in the parenchyma and pancreatic duct. Furthermore to evaluate the exocrine function many indirect and direct methods are available. Fecal elastase 1 (FE 1) is one of the commonly used indirect method which is easy to perform but has low sensitivity and its utility in diagnosing CP is controversial (7, 16, 50). Tubed secretin test is a direct method which involves prolonged intubation and serial collection of pancreatic juice after hormonal stimulation is considered as a reference standard for the evaluation of exocrine function of pancreas in spite of many issues with this technique (5, 43). Secretin enhanced Magnetic Resonance Cholangio-Pancreatography (S-MRCP) in which secretin is used to stimulate the pancreatic juice is emerging as a one stop shop modality for the evaluation of both structural and functional aspects in CP (43). Advancements have been made in MRI technique in which diffusion weighted imaging (DWI) along with apparent diffusion co-efficient (ADC) can be used to study the microscopic diffusion of water molecules. This can give a unique insight in to the tissue characteristics of pancreas which will be discussed later in this chapter (2, 18, 38)." @default.
• W1165431427 created "2016-06-24" @default.
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• W1165431427 date "2015-07-19" @default.
• W1165431427 modified "2023-10-01" @default.
• W1165431427 title "Imaging in Chronic Pancreatitis" @default.
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• W1165431427 doi "https://doi.org/10.3998/panc.2015.26" @default.
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