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• W1165773436 abstract "The story of cyclic dimeric GMP (c-di-GMP), the subject of this chapter, now recognized as a universal bacterial second messenger. A cellulose molecule is a homopolymer of D-glucose residues linked in β-1,4-glucosidic bonds. The nature of the immediate precursor of cellulose, UDP-glucose, has been identified, and the biochemical pathways leading to its formation have been established. The work of Moshe Benziman, his students, and his colleagues, who studied cellulose biosynthesis in a relatively simple bacterial model, made a major contribution toward a better understanding of cellulose biosynthesis. The complexity of the plant cell wall biogenesis makes studies of the cellulose biosynthesis in plants a very difficult task and prompted the search for a more convenient experimental model. A series of experiments was aimed at pinpointing the cellulose biosynthesis pathway and identifying the immediate precursor of cellulose. The discovery of the GTP-mediated activation of cellulose synthase provided the platform for an important advance, solubilization of the high-activity enzyme system while preserving its capability to respond to the GTP-mediated regulatory mechanism. The finding that the regulatory protein, necessary for activation of the Gluconacetobacter xylinus cellulose synthase, was actually a diguanylate cyclase (cyclic Di-GMP (c-di-GMP) synthase, DGC) constituted a key step toward characterization of the enzymes involved in biosynthesis and hydrolysis of c-di-GMP. The discovery of c-di-GMP presented a tempting platform to study molecular pathways possibly connected to this nucleotide, not only in other bacteria but also in eukaryotic systems." @default.
• W1165773436 created "2016-06-24" @default.
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• W1165773436 date "2014-04-30" @default.
• W1165773436 modified "2023-09-28" @default.
• W1165773436 title "Moshe Benziman and the Discovery of Cyclic Di-GMP" @default.
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• W1165773436 doi "https://doi.org/10.1128/9781555816667.ch2" @default.
• W1165773436 hasPublicationYear "2014" @default.
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