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- W1165783485 endingPage "61" @default.
- W1165783485 startingPage "41" @default.
- W1165783485 abstract "Mitochondria play a critical role in controlling both cellular metabolism and the initiation of apoptosis. Therefore for cell survival, the maintenance of a healthy pool of mitochondria is essential, particularly for cell types such as neurons that are very reliant on ATP generated by oxidative phosphorylation. Damaged/dysfunctional mitochondria are degraded by macroautophagy. This pathway has been termed mitophagy. There is increasing evidence that impaired mitophagy contributes to the mitochondrial dysfunction associated with several diseases, and in particular neurological disorders such as Parkinson’s disease. Given the central involvement of mitochondria in cellular metabolism it is emerging that these organelles also appear to play a role in starvation-induced macroautophagy, ranging from providing membrane for synthesis of new phagophores to acting as hubs for autophagic proteins to initiate and control macroautophagy. The mechanisms by which damaged mitochondria are selectively removed by mitophagy and how impairment of this process may contribute to neurodegenerative disorders, in addition to the putative role of healthy mitochondria integrating cellular metabolism with autophagy will be described in this chapter." @default.
- W1165783485 created "2016-06-24" @default.
- W1165783485 creator A5070560226 @default.
- W1165783485 date "2015-01-01" @default.
- W1165783485 modified "2023-09-27" @default.
- W1165783485 title "Interaction Between Mitochondria and Autophagy" @default.
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