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- W1165882598 abstract "Knowledge of the immune responses which develop in cattle following infection withMycobacterium bovis is essential both to the understanding of disease pathogenesis and to thelogical development of immune-dependent tools, such as diagnostic tests and vaccines, whichcan be used to combat the disease (Pollock et al., 2001). The early, preclinical stages ofbovine TB can be detected in live animals by the use of tests of cellular immunity (the skin, cinterferonand lymphocyte transformation tests)(de la Rua-Domenech et al., 2006). Intuberculosis, both macrophages and lymphocytes are sensitized to tuberculin, which in lowconcentrations is capable of inducing their activation both in vivo and in vitro. This studyaimed to evaluate the diagnostic relevance of monitoring adaptive cell-mediated responsessuch as skin test (IDR), gamma interferon (IFN) synthesis (Bovigam TM, ELISA test), invitro blast transformation test (RPMI 1640 medium, 72 h incubation) and leukocyte migrationinhibition tests (RPMI 1640 medium, 18 h incubation) to avian and bovine tuberculins. Theskin test was performed on 79 Romanian spotted adult bovine, aged 5 to 10 years. Bloodsamples on heparin (50 IU/ml) were taken from the 34 IDR positive animals (1.14±0.83 mmand 7.28±1.58 mm responses to avian and bovine tuberculin, respectively, accompanied bylocal edema) and subjected to the other cell mediated immunity tests. Correlation coefficientsbetween the tests were calculated. No significant correlation between the IDR and IFN forthe bovine tuberculin, yet a strong positive correlation (p<0.001) for the avian tuberculin wereobtained, suggesting the independent variation of the two indicators. Both IDR - leukocytemigration (r = 0.513, p< 0.01) and IDR-blast transformation (r = 0.592, p< 0.001) correlationswere positive and statistically significant, when bovine tuberculin was used. We concludedthat the latter two tests could be used when specific sensitization to M. tuberculosis bovinesubtype is to be detected in IDR positive animals." @default.
- W1165882598 created "2016-06-24" @default.
- W1165882598 creator A5085830541 @default.
- W1165882598 date "2010-01-01" @default.
- W1165882598 modified "2023-09-28" @default.
- W1165882598 title "A Correlative Evaluation of the Diagnostic Importance of Adaptive Cell- Mediated Tests in Bovine Tuberculosis" @default.
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- W1165882598 doi "https://doi.org/10.15835/buasvmcn-vm:67:2:6035" @default.
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