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- W1166018334 abstract "Mycolactones are a family of lipophilic small molecules and virulence factors produced as secondary metabolites by Mycobacterium ulcerans and some highly related aquatic mycobacteria. This chapter describes what is known about mycolactones and their unique role in the pathogenesis of Buruli ulcer, explains their unusual biosynthetic locus, and highlights the key questions that remain to be answered. A recent report describes an abundant extracellular matrix produced by M. ulcerans that harbors vesicles that are rich in mycolactones. Mycolactones are related to antibacterial macrolides such as erythromycin and immunosuppressants such as FK506 because they all share a polyketide-derived macrolactone core. The apoptotic ability of mycolactone F is significantly less than that of the other mycolactones; a feature that may be associated with its shorter acyl side chain. All of these mycolactone-producing mycobacteria, including M. ulcerans, form a distinct lineage within a genetically more diverse assemblage of Mycobacterium marinum that have clearly evolved from a common M. marinum-like progenitor. All mycolactone-producing mycobacteria found so far have been discovered through their ability to cause disease in vertebrates, but they may be acting as “indicator” species and represent only a proportion of the mycolactones that exist in nature." @default.
- W1166018334 created "2016-06-24" @default.
- W1166018334 creator A5035786218 @default.
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- W1166018334 date "2014-04-30" @default.
- W1166018334 modified "2023-09-23" @default.
- W1166018334 title "The Mycolactones: Biologically Active Polyketides Produced by Mycobacterium ulcerans and Related Aquatic Mycobacteria" @default.
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- W1166018334 doi "https://doi.org/10.1128/9781555815783.ch22" @default.
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