Matches in SemOpenAlex for { <https://semopenalex.org/work/W1166858611> ?p ?o ?g. }
- W1166858611 endingPage "187" @default.
- W1166858611 startingPage "179" @default.
- W1166858611 abstract "Exercise training has an anti-tumor effect and can reduce tumor growth; however, the exact underlying mechanisms of its protective effects are still obscure. MicroRNA (miR)-21 is a predictor in cancer survival, and has a potential use as an indicator of therapeutic outcome in breast malignancies. Forty-eight female BALB/c mice were equally divided into six groups to investigate the effects of interval exercise training with tamoxifen on miR-21 expression and its possible assumed mechanisms in an estrogen receptor-positive breast cancer model. ELISA, immunohistochemistry, western blot, qRT-PCR assays were performed at the end of the study. Tumor size was significantly declined in exercise training and tamoxifen groups compared to tumor group (P<0.05). Expression of miR-21 was significantly down-regulated in trained and tamoxifen treated mice in comparison with tumor group (P<0.05). Exercise training was as effective as tamoxifen treatment in decreasing serum estradiol and ER-α expression (P<0.05). Exercise training and tamoxifen reduced tumor IL-6 levels, NF-kB and STAT3 expressions, and up-regulated TPM1 and PDCD4 expressions (P<0.05). Both exercise and tamoxifen had synergistic effects in reducing miR-21 and Bcl-2, and up-regulating PDCD4 expression. Results showed that interval exercise training may reduce mammary tumor burden in mice through possible underlying pathway of miR-21." @default.
- W1166858611 created "2016-06-24" @default.
- W1166858611 creator A5001230496 @default.
- W1166858611 creator A5002850440 @default.
- W1166858611 creator A5004588764 @default.
- W1166858611 creator A5016527060 @default.
- W1166858611 creator A5021349148 @default.
- W1166858611 creator A5023148240 @default.
- W1166858611 creator A5027521870 @default.
- W1166858611 creator A5045961536 @default.
- W1166858611 creator A5047443011 @default.
- W1166858611 creator A5058589108 @default.
- W1166858611 creator A5062413646 @default.
- W1166858611 creator A5072483165 @default.
- W1166858611 creator A5073316581 @default.
- W1166858611 creator A5078754068 @default.
- W1166858611 date "2015-10-01" @default.
- W1166858611 modified "2023-10-16" @default.
- W1166858611 title "Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: Possible underlying pathway of miR-21" @default.
- W1166858611 cites W144423133 @default.
- W1166858611 cites W1648301895 @default.
- W1166858611 cites W1779691448 @default.
- W1166858611 cites W1961010966 @default.
- W1166858611 cites W1971548442 @default.
- W1166858611 cites W1972250842 @default.
- W1166858611 cites W1972892962 @default.
- W1166858611 cites W1973354465 @default.
- W1166858611 cites W1973887803 @default.
- W1166858611 cites W1978147177 @default.
- W1166858611 cites W1981303092 @default.
- W1166858611 cites W1986834354 @default.
- W1166858611 cites W1989853294 @default.
- W1166858611 cites W1990771795 @default.
- W1166858611 cites W1991532146 @default.
- W1166858611 cites W2007242949 @default.
- W1166858611 cites W2008955962 @default.
- W1166858611 cites W2010180766 @default.
- W1166858611 cites W2030642613 @default.
- W1166858611 cites W2040068042 @default.
- W1166858611 cites W2042470379 @default.
- W1166858611 cites W2042714596 @default.
- W1166858611 cites W2044227662 @default.
- W1166858611 cites W2050079849 @default.
- W1166858611 cites W2057633846 @default.
- W1166858611 cites W2059382687 @default.
- W1166858611 cites W2061851373 @default.
- W1166858611 cites W2069104846 @default.
- W1166858611 cites W2074146582 @default.
- W1166858611 cites W2077672263 @default.
- W1166858611 cites W2085609942 @default.
- W1166858611 cites W2090506708 @default.
- W1166858611 cites W2096291441 @default.
- W1166858611 cites W2096433394 @default.
- W1166858611 cites W2096573862 @default.
- W1166858611 cites W2103211592 @default.
- W1166858611 cites W2103361158 @default.
- W1166858611 cites W2104610341 @default.
- W1166858611 cites W2110413857 @default.
- W1166858611 cites W2114280375 @default.
- W1166858611 cites W2116554142 @default.
- W1166858611 cites W2123343597 @default.
- W1166858611 cites W2131523986 @default.
- W1166858611 cites W2135836598 @default.
- W1166858611 cites W2157038349 @default.
- W1166858611 cites W2167715370 @default.
- W1166858611 cites W2171201030 @default.
- W1166858611 cites W4238260078 @default.
- W1166858611 doi "https://doi.org/10.1016/j.ejphar.2015.08.031" @default.
- W1166858611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26300395" @default.
- W1166858611 hasPublicationYear "2015" @default.
- W1166858611 type Work @default.
- W1166858611 sameAs 1166858611 @default.
- W1166858611 citedByCount "57" @default.
- W1166858611 countsByYear W11668586112015 @default.
- W1166858611 countsByYear W11668586112016 @default.
- W1166858611 countsByYear W11668586112017 @default.
- W1166858611 countsByYear W11668586112018 @default.
- W1166858611 countsByYear W11668586112019 @default.
- W1166858611 countsByYear W11668586112020 @default.
- W1166858611 countsByYear W11668586112021 @default.
- W1166858611 countsByYear W11668586112022 @default.
- W1166858611 countsByYear W11668586112023 @default.
- W1166858611 crossrefType "journal-article" @default.
- W1166858611 hasAuthorship W1166858611A5001230496 @default.
- W1166858611 hasAuthorship W1166858611A5002850440 @default.
- W1166858611 hasAuthorship W1166858611A5004588764 @default.
- W1166858611 hasAuthorship W1166858611A5016527060 @default.
- W1166858611 hasAuthorship W1166858611A5021349148 @default.
- W1166858611 hasAuthorship W1166858611A5023148240 @default.
- W1166858611 hasAuthorship W1166858611A5027521870 @default.
- W1166858611 hasAuthorship W1166858611A5045961536 @default.
- W1166858611 hasAuthorship W1166858611A5047443011 @default.
- W1166858611 hasAuthorship W1166858611A5058589108 @default.
- W1166858611 hasAuthorship W1166858611A5062413646 @default.
- W1166858611 hasAuthorship W1166858611A5072483165 @default.
- W1166858611 hasAuthorship W1166858611A5073316581 @default.
- W1166858611 hasAuthorship W1166858611A5078754068 @default.
- W1166858611 hasConcept C104317684 @default.