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• W1168368082 abstract "<b>Objective</b> We set out to examine rates of perinatal mortality in twin pregnancies over a 17-year study period. Changes in mode of delivery were also examined as well as causes of death in twin mortalities. <b>Study Design</b> This retrospective cohort study was performed at three large tertiary referral centers from 1996 to 2012. It included all normally formed twin infants with a birth weight more than 500 g. All cases of perinatal mortality in twin pregnancies (infants more than 500 g who suffered an intrauterine or early neonatal (≤ 7 days of age) death were recorded. The changing rate of cesarean delivery as well as varying causes of death in twins over the course of the study were also examined. <b>Results</b> During the study period, there were 395,830 pregnancies across the three institutions, this included 6,727 twin gestations. The perinatal mortality rate was 21.5/1,000 twin infants. The perinatal mortality rate in twins decreased over the study period (<i>p</i> = 0.0006; <i>R</i> ² = 0.55; slope = −1.2). Rates of cesarean delivery in twin gestations were found to have increased over the course of the study (<i>p</i> < 0.0001; <i>R</i> ² = 0.84; slope = 1.7). There were 288 intrauterine and early neonatal deaths in twin infants, 50% (147/288) occurred in twins born extremely premature (< 26 weeks). Prematurity was the leading cause of mortality in twins, followed by twin-to-twin transfusion syndrome (TTTS). TTTS was found to have a decreasing contribution to perinatal mortality during the study (<i>p</i> = 0.008; <i>R</i> ² = 0.38; slope = −1.5). <b>Conclusion</b> The perinatal mortality rate in twins improved during the study. The rate of cesarean delivery increased by 1.7% for each year of the study, culminating in a cesarean delivery rate of 62% in 2012. TTTS made a decreasing contribution to the mortality rate in twins during the study." @default.
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• W1168368082 date "2015-08-21" @default.
• W1168368082 modified "2023-10-14" @default.
• W1168368082 title "Improved Perinatal Mortality in Twins—Changing Practice and Technologies" @default.
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• W1168368082 doi "https://doi.org/10.1055/s-0035-1559807" @default.
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