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• W1168474682 abstract "MicroRNAs have become recognized as key players in the development of malignancy. They are a family of small non-coding RNAs (22 nt~30 nt) that can negatively regulate the expression of cancer-related genes by sequence selective targeting of mRNAs, leading to either mRNA translational repression or degradation. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. In this study, we analyzed the expression profile of miR-34c-3p in non-small cell lung cancer (NSCLC) tissues and cell lines, as its participation in some other types of cancer has been shown by previous reports. We found that miR-34c-3p was downregulated both in NSCLC tissues and cell lines. Overexpression of miR-34c-3p suppressed cell proliferation and colony formation and also limited migration and invasion in A549 cells. Furthermore, our results also shown miR-34c-3p reduction was associated with increased PAC1 expression levels in which miR-34c-3p downregulated PAC1 expression by recognizing and binding to specific binding sites in PAC1 3'-UTR. Taken together, our study implicates important roles of miR-34c-3p in NSCLC pathogenesis and implicates its potential application in cancer therapy." @default.
• W1168474682 created "2016-06-24" @default.
• W1168474682 creator A5004269850 @default.
• W1168474682 creator A5082157709 @default.
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• W1168474682 date "2015-01-01" @default.
• W1168474682 modified "2023-09-25" @default.
• W1168474682 title "MiR-34c-3p suppresses the proliferation and invasion of non-small cell lung cancer (NSCLC) by inhibiting PAC1/MAPK pathway." @default.
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• W1168474682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4525841" @default.
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• W1168474682 hasPublicationYear "2015" @default.
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