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- W116848897 abstract "The targeting of radionuclides with antibodies has been a very productive line of investigation for many years. Starting in the middle of the last century at a time before well-defined tumor markers were available, this effort has been at the center of a host of innovations, including the development of monoclonal antibodies, molecularly engineered antibodies and other antibody-related compounds, new procedures for manufacturing radionuclides, and their coupling to antibodies. Progress has led to the approval of two therapeutic agents for select lymphomas, but the therapeutic window is limited by hematological toxicity because the radioactivity bound to an antibody stays in the bloodstream for extended periods. Antibody fragments reduce red marrow exposure, but have not enhanced the therapeutic window sufficiently. An alternative approach known as pretargeting greatly reduces the radioactivity’s residence time in the blood and accelerates the time to maximum tumor accretion while maintaining high tumor uptake. This chapter focuses on the progress being made in using bispecific antibody pretargeting for improved delivery of therapeutic radionuclides." @default.
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- W116848897 date "2012-01-01" @default.
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- W116848897 title "Radioimmunotherapy of Tumors: Pretargeting with Bispecific Antibodies" @default.
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- W116848897 doi "https://doi.org/10.1007/174_2012_679" @default.
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