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- W1168566532 endingPage "59" @default.
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- W1168566532 abstract "Most filamentous fungi are exquisitely sensitive to changes in their environment. Sensing and integration of signals from multiple sources require a complex web of signal transduction pathways. This chapter covers major signal transduction pathways that have been characterized in multiple species of filamentous fungi. The signaling pathways included are monomeric and heterotrimeric GTP-binding proteins, mitogen-activated protein kinases (MAPKs), protein kinase A/cyclic AMP (PKA/cAMP) signaling, two-component regulatory systems, calcium signaling, target of rapamycin (Tor) pathways and pH regulatory mechanisms. With the exception of two-component systems, related pathways are found in animals, where they also play fundamental roles. In general, the elements of these systems are found in all fungal species that have been sequenced; however, the number of genes representing each signaling protein class often varies. In spite of this conservation, several interesting variations in how pathway components are arranged or regulated have also emerged. Furthermore, accumulating evidence indicates that multiple pathways often cooperate to regulate the same function in the same species, resulting in more complex signal transduction networks. The response regulators from two-component regulatory systems have also been shown to regulate Hog1p-like cascades in filamentous fungi. Two-component regulatory systems are major signal transduction pathways in filamentous fungi." @default.
- W1168566532 created "2016-06-24" @default.
- W1168566532 creator A5028914786 @default.
- W1168566532 creator A5048795660 @default.
- W1168566532 creator A5060145183 @default.
- W1168566532 date "2014-04-30" @default.
- W1168566532 modified "2023-09-27" @default.
- W1168566532 title "Signal Transduction Pathways" @default.
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