Matches in SemOpenAlex for { <https://semopenalex.org/work/W1169015573> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1169015573 abstract "The accepted clinical method to accommodate targeting uncertainties inherent in fractionated external beam radiation therapy is to utilize GTV-to-CTV and CTV-to-PTV margins during the planning process to design a PTV-conformal static dose distribution on the planning image set. Ideally, margins are selected to ensure a high (e.g. >95%) target coverage probability (CP) in spite of inherent inter- and intra-fractional positional variations, tissue motions, and initial contouring uncertainties.Robust optimization techniques, also known as probabilistic treatment planning techniques, explicitly incorporate the dosimetric consequences of targeting uncertainties by including CP evaluation into the planning optimization process along with coverage-based planning objectives. The treatment planner no longer needs to use PTV and/or PRV margins; instead robust optimization utilizes probability distributions of the underlying uncertainties in conjunction with CP-evaluation for the underlying CTVs and OARs to design an optimal treated volume.This symposium will describe CP-evaluation methods as well as various robust planning techniques including use of probability-weighted dose distributions, probability-weighted objective functions, and coverage optimized planning. Methods to compute and display the effect of uncertainties on dose distributions will be presented. The use of robust planning to accommodate inter-fractional setup uncertainties, organ deformation, and contouring uncertainties will be examined as will its use to accommodate intra-fractional organ motion. Clinical examples will be used to inter-compare robust and margin-based planning, highlighting advantages of robust-plans in terms of target and normal tissue coverage. Robust-planning limitations as uncertainties approach zero and as the number of treatment fractions becomes small will be presented, as well as the factors limiting clinical implementation of robust planning.Learning Objectives:1. To understand robust-planning as a clinical alternative to using margin-based planning.2. To understand conceptual differences between uncertainty and predictable motion.3. To understand fundamental limitations of the PTV concept that probabilistic planning can overcome.4. To understand the major contributing factors to target and normal tissue coverage probability.5. To understand the similarities and differences of various robust planning techniques6. To understand the benefits and limitations of robust planning techniques" @default.
- W1169015573 created "2016-06-24" @default.
- W1169015573 creator A5053597888 @default.
- W1169015573 date "2015-06-01" @default.
- W1169015573 modified "2023-09-27" @default.
- W1169015573 title "TU-AB-BRB-02: Stochastic Programming Methods for Handling Uncertainty and Motion in IMRT Planning" @default.
- W1169015573 doi "https://doi.org/10.1118/1.4925504" @default.
- W1169015573 hasPublicationYear "2015" @default.
- W1169015573 type Work @default.
- W1169015573 sameAs 1169015573 @default.
- W1169015573 citedByCount "0" @default.
- W1169015573 crossrefType "journal-article" @default.
- W1169015573 hasAuthorship W1169015573A5053597888 @default.
- W1169015573 hasConcept C105795698 @default.
- W1169015573 hasConcept C119857082 @default.
- W1169015573 hasConcept C121684516 @default.
- W1169015573 hasConcept C126255220 @default.
- W1169015573 hasConcept C126322002 @default.
- W1169015573 hasConcept C149441793 @default.
- W1169015573 hasConcept C154945302 @default.
- W1169015573 hasConcept C193254401 @default.
- W1169015573 hasConcept C201645570 @default.
- W1169015573 hasConcept C2779104521 @default.
- W1169015573 hasConcept C33923547 @default.
- W1169015573 hasConcept C41008148 @default.
- W1169015573 hasConcept C49937458 @default.
- W1169015573 hasConcept C509974204 @default.
- W1169015573 hasConcept C71924100 @default.
- W1169015573 hasConcept C774472 @default.
- W1169015573 hasConceptScore W1169015573C105795698 @default.
- W1169015573 hasConceptScore W1169015573C119857082 @default.
- W1169015573 hasConceptScore W1169015573C121684516 @default.
- W1169015573 hasConceptScore W1169015573C126255220 @default.
- W1169015573 hasConceptScore W1169015573C126322002 @default.
- W1169015573 hasConceptScore W1169015573C149441793 @default.
- W1169015573 hasConceptScore W1169015573C154945302 @default.
- W1169015573 hasConceptScore W1169015573C193254401 @default.
- W1169015573 hasConceptScore W1169015573C201645570 @default.
- W1169015573 hasConceptScore W1169015573C2779104521 @default.
- W1169015573 hasConceptScore W1169015573C33923547 @default.
- W1169015573 hasConceptScore W1169015573C41008148 @default.
- W1169015573 hasConceptScore W1169015573C49937458 @default.
- W1169015573 hasConceptScore W1169015573C509974204 @default.
- W1169015573 hasConceptScore W1169015573C71924100 @default.
- W1169015573 hasConceptScore W1169015573C774472 @default.
- W1169015573 hasLocation W11690155731 @default.
- W1169015573 hasOpenAccess W1169015573 @default.
- W1169015573 hasPrimaryLocation W11690155731 @default.
- W1169015573 hasRelatedWork W1436734099 @default.
- W1169015573 hasRelatedWork W1441720098 @default.
- W1169015573 hasRelatedWork W2005765459 @default.
- W1169015573 hasRelatedWork W2059423231 @default.
- W1169015573 hasRelatedWork W2077415334 @default.
- W1169015573 hasRelatedWork W2106887979 @default.
- W1169015573 hasRelatedWork W2113750341 @default.
- W1169015573 hasRelatedWork W2188963148 @default.
- W1169015573 hasRelatedWork W2219244767 @default.
- W1169015573 hasRelatedWork W2512017547 @default.
- W1169015573 hasRelatedWork W2597302326 @default.
- W1169015573 hasRelatedWork W2609774322 @default.
- W1169015573 hasRelatedWork W2755193946 @default.
- W1169015573 hasRelatedWork W2766995857 @default.
- W1169015573 hasRelatedWork W2950519733 @default.
- W1169015573 hasRelatedWork W3045228861 @default.
- W1169015573 hasRelatedWork W3104775591 @default.
- W1169015573 hasRelatedWork W3178157366 @default.
- W1169015573 hasRelatedWork W3197240003 @default.
- W1169015573 hasRelatedWork W1969660709 @default.
- W1169015573 isParatext "false" @default.
- W1169015573 isRetracted "false" @default.
- W1169015573 magId "1169015573" @default.
- W1169015573 workType "article" @default.