FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W117001785> ?p ?o ?g. }

• W117001785 endingPage "62" @default.
• W117001785 startingPage "355" @default.
• W117001785 abstract "An in vitro-chemosensitivity test using the collagen gel droplet embedded culture drug test (CD-DST), established by Kobayashi et al. (Jpn J Cancer Res 2001; 92: 203-10), has been widely used on various tumors. This study retrospectively evaluated its possibility of clinical application to patients with malignant pleural mesothelioma (MPM).CD-DST using 26 fresh specimens obtained by biopsy or surgery on MPM patients investigated in vitro responses to cisplatin (CDDP), carboplatin (CBDCA), doxorubicin (ADR), etoposide (VP-16), 5-fluoruracil (5-FU), gemcitabine (GEM), vinorelbine (VNR), irinotecan (SN-38), and docetaxel (TXT). Correlations between CD-DST data and clinical effects were then assessed for some MPM patients undergoing chemotherapy.The rate of in vitro sensitivity to each chemoagent (N=tested number) was 35% for CDDP (N=23), 14% for CBDCA (N=21), 7% for ADR (N=15), 15% for VP-16 (N=13), 0% for 5-FU (N=15), 45% for GEM (N=11), 25% for VNR (N=8), 40% for SN-38 (N=5), and 44% for TXT (N=9). No difference was observed between CD-DST data of each chemoagent and histological type. Of these MPM patients, 14 clinical effects on 13 patients who underwent chemotherapy for primary or recurrent disease were reviewed in comparison with CD-DST data of each chemoagent. Among 10 chemotherapies including in vitro-sensitive chemoagents, 3 led to partial response (PR), and 7 resulted in four stable diseases (SDs) and 3 to progressive diseases (PDs). In contrast, among 4 chemotherapies using in vitro-resistant chemoagents, SD and PD were observed in 1 and 3, respectively. In regard to the clinical response rate, CD-DST sensitivity, specificity, and accuracy in the 14 examined chemotherapies were respectively 100%, 36%, and 50%, and in regard to the disease control rate, they were 88%, 60%, and 71%. CD-DST data for the chemoagents were to a limited extent significantly correlated with the disease control status of chemotherapy (p=0.052).Although the number of tested MPM specimens was small, CD-DST data obtained by biopsy or surgical-fresh specimens of MPM marginally correlated to the disease control effect of chemotherapy for this disease. Therefore CD-DST may possibly be applied to selecting the chemotherapy regimen for MPM. To determine the possibility of a clinical application of this test to MPM, a prospective clinical study of a greater number of patients will be necessary." @default.
• W117001785 created "2016-06-24" @default.
• W117001785 creator A5022913307 @default.
• W117001785 creator A5030178636 @default.
• W117001785 creator A5036204627 @default.
• W117001785 creator A5061233614 @default.
• W117001785 creator A5068643063 @default.
• W117001785 creator A5069500633 @default.
• W117001785 creator A5074805114 @default.
• W117001785 creator A5076968285 @default.
• W117001785 creator A5091248337 @default.
• W117001785 date "2008-12-01" @default.
• W117001785 modified "2023-09-23" @default.
• W117001785 title "In vitro-chemosensitivity test using the collagen gel droplet embedded culture drug test (CD-DST) for malignant pleural mesothelioma: possibility of clinical application." @default.
• W117001785 cites W184745523 @default.
• W117001785 cites W1869777220 @default.
• W117001785 cites W1979021710 @default.
• W117001785 cites W1987118598 @default.
• W117001785 cites W1987299492 @default.
• W117001785 cites W1989459792 @default.
• W117001785 cites W1993568439 @default.
• W117001785 cites W2012809050 @default.
• W117001785 cites W2016738340 @default.
• W117001785 cites W2019858127 @default.
• W117001785 cites W2034433264 @default.
• W117001785 cites W2054624164 @default.
• W117001785 cites W2057434277 @default.
• W117001785 cites W2075203666 @default.
• W117001785 cites W2081482934 @default.
• W117001785 cites W2084906915 @default.
• W117001785 cites W2088425388 @default.
• W117001785 cites W2091003848 @default.
• W117001785 cites W2100576484 @default.
• W117001785 cites W2102627969 @default.
• W117001785 cites W2113029332 @default.
• W117001785 cites W2125980018 @default.
• W117001785 cites W2127235139 @default.
• W117001785 cites W2137953688 @default.
• W117001785 cites W2163456861 @default.
• W117001785 cites W2211105205 @default.
• W117001785 cites W2242746637 @default.
• W117001785 cites W2412618962 @default.
• W117001785 cites W2462483769 @default.
• W117001785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19131921" @default.
• W117001785 hasPublicationYear "2008" @default.
• W117001785 type Work @default.
• W117001785 sameAs 117001785 @default.
• W117001785 citedByCount "10" @default.
• W117001785 countsByYear W1170017852012 @default.
• W117001785 countsByYear W1170017852013 @default.
• W117001785 countsByYear W1170017852015 @default.
• W117001785 countsByYear W1170017852019 @default.
• W117001785 countsByYear W1170017852021 @default.
• W117001785 crossrefType "journal-article" @default.
• W117001785 hasAuthorship W117001785A5022913307 @default.
• W117001785 hasAuthorship W117001785A5030178636 @default.
• W117001785 hasAuthorship W117001785A5036204627 @default.
• W117001785 hasAuthorship W117001785A5061233614 @default.
• W117001785 hasAuthorship W117001785A5068643063 @default.
• W117001785 hasAuthorship W117001785A5069500633 @default.
• W117001785 hasAuthorship W117001785A5074805114 @default.
• W117001785 hasAuthorship W117001785A5076968285 @default.
• W117001785 hasAuthorship W117001785A5091248337 @default.
• W117001785 hasConcept C121608353 @default.
• W117001785 hasConcept C126322002 @default.
• W117001785 hasConcept C142724271 @default.
• W117001785 hasConcept C143998085 @default.
• W117001785 hasConcept C185592680 @default.
• W117001785 hasConcept C202751555 @default.
• W117001785 hasConcept C2776694085 @default.
• W117001785 hasConcept C2777407522 @default.
• W117001785 hasConcept C2778076430 @default.
• W117001785 hasConcept C2778119113 @default.
• W117001785 hasConcept C2778239845 @default.
• W117001785 hasConcept C2780258809 @default.
• W117001785 hasConcept C2780259306 @default.
• W117001785 hasConcept C2780350996 @default.
• W117001785 hasConcept C2781190966 @default.
• W117001785 hasConcept C2781303535 @default.
• W117001785 hasConcept C2781451048 @default.
• W117001785 hasConcept C526805850 @default.
• W117001785 hasConcept C55493867 @default.
• W117001785 hasConcept C71924100 @default.
• W117001785 hasConceptScore W117001785C121608353 @default.
• W117001785 hasConceptScore W117001785C126322002 @default.
• W117001785 hasConceptScore W117001785C142724271 @default.
• W117001785 hasConceptScore W117001785C143998085 @default.
• W117001785 hasConceptScore W117001785C185592680 @default.
• W117001785 hasConceptScore W117001785C202751555 @default.
• W117001785 hasConceptScore W117001785C2776694085 @default.
• W117001785 hasConceptScore W117001785C2777407522 @default.
• W117001785 hasConceptScore W117001785C2778076430 @default.
• W117001785 hasConceptScore W117001785C2778119113 @default.
• W117001785 hasConceptScore W117001785C2778239845 @default.
• W117001785 hasConceptScore W117001785C2780258809 @default.
• W117001785 hasConceptScore W117001785C2780259306 @default.
• W117001785 hasConceptScore W117001785C2780350996 @default.
• W117001785 hasConceptScore W117001785C2781190966 @default.

• next