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- W1170092097 abstract "Advancement in medical therapies requires clinical research to test a therapy's efficacy and safety in humans, yet this process can be slow, inefficient, and error prone. Two key problems resulting in delays are: 1) the translation of research ideas into relevant, testable hypotheses, and 2) the enrollment of subjects in clinical research that test these hypotheses. A crucial need for computational support is indicated by several challenges: the complex nature of the medical field, the large number of possible health hypotheses, and the variety and size of clinical research data. Strong social and economic forces are changing the way healthcare works. Clinical research is evolving to emphasize increased efficiencies, productivity, and inclusion of health-consumer-centered outcomes. In the period of change, this research seeks to address these challenges through the design of a Health Research Exchange (HRE) that is a development and communication hub for health research hypotheses. The HRE improves upon existing health research databases, such as clinicaltrials.gov, by addressing the process of hypothesis formation. It seeks to facilitate health hypothesis development by non-medical professionals, enabling health research to become more relevant to health consumers.The HRE is centered on the innovative Molecular Hypothesis Model (MoHM), featuring structured representation and reasoning about health hypotheses. The MoHM m 2) a hypothesis management capability, leveraging MoHM connectivity and modularity to provide support for construction and querying of hypotheses, and 3) a hypothesis collaboration protocol, enabling progressive engagement in health research collaboration, and efficient matching of health profiles to health research. These innovations are illustrated in the context of several health research examples." @default.
- W1170092097 created "2016-06-24" @default.
- W1170092097 creator A5021303314 @default.
- W1170092097 date "2013-01-01" @default.
- W1170092097 modified "2023-09-27" @default.
- W1170092097 title "The Health Research Exchange: A collaborative model for improving participation in health research" @default.
- W1170092097 hasPublicationYear "2013" @default.
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