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- W1170173886 abstract "Histone-reactive antibodies hold a preeminent position in the history of fundamental discoveries in autoimmunity. Patients with lupus-like disorders commonly have autoantibodies to histone–DNA complexes, and the (H2A-H2B)–DNA complex largely accounts for reactivity to these higher order structures in chromatin. In SLE, antibodies requiring native forms of nucleohistone dominate the autoantibody serology, although antibodies to DNA free histones (really anti-denatured histone antibodies) are commonly present at a lower titer. Antihistone antibodies can be found in all the major immunoglobulin classes in patients with SLE and there is little agreement as to the predominant isotype. Studies on the association of antihistone antibodies with disease activity or severity, with the predominant organ system affected, or with specific clinical features have been inconsistent. Rheumatoid arthritis (RA ) patients with antihistone antibodies did not display more active disease than antihistone antibodynegative RA patients. The specificity of histone-reactive antibodies in SLE and in lupus induced by most drugs is consistent with some form of chromatin being the predominant in vivo immunogen driving these B-cell responses. The pathogenic mechanisms in SLE have not been clearly elucidated, but there is a general consensus that complexes between autoantibody and its cognate antigen play at least a contributing role." @default.
- W1170173886 created "2016-06-24" @default.
- W1170173886 creator A5037032256 @default.
- W1170173886 date "2004-01-01" @default.
- W1170173886 modified "2023-09-24" @default.
- W1170173886 title "ANTIHISTONE ANTIBODIES" @default.
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