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- W117041884 abstract "OBJETIVE. We conducted a prospective study with the aim to compare the efectiveness in preventing surgical site infections. Wetested single dose of cefazolin admistration with 24h regimen in adults undergoing cardiac surgery procedures. We performeda cost�efectiveness study and risk factors analysis for the development of surgical site infections. MATERIALS AND METHODS. Weincluded 838 adult cardiac surgery patients and were randomly given a single dose of cefazolin or 24 h treatment. Followupwas conducted in patients during one year for the diagnosis of post-operative endocarditis in early stage of development.We performed univariate and multivariate analysis and multiple logistic regresion analysis for the adjustment of potencialcofounders. RESULTS. 419 patients received single-dose cefazolin, and another 419 received the 24-hour treatment. Surgical site infection occurred in 50 patients. In 22 cases were organ-space infections. We identified no differences between groupsfor mortality or duration of hospitalization (preoperative hospitalization, intensive care unit stay, and hospitalization aftersurgical intervention). The type of antibiotic prophylaxis given was not identified as a risk factor for development of infectionor organ space. In multivariate analysis, the development of respiratory insufficiency during the post-operative period, evidenceof microorganisms isolated from blood samples and post-operative stay in ICU were risk factors for the development oforgan or space infections during the post-operative period of cardiac surgery. CONCLUSIONS. Single dose of cefazolin treatmentis less effective than 24h treatment in adults undergoing cardiac procedures for the prevention of surgical site infections. Postoperativerespiratory insufficiency, the evidence of positive blood samples and prolonged stay in the intensive care unit aresignificant risk factors for developing organ or space infections during the post-operative period of cardiac surgery." @default.
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- W117041884 date "2009-01-01" @default.
- W117041884 modified "2023-09-23" @default.
- W117041884 title "Profilaxis antibiótica en cirugía cardíaca: Análisis de los factores de riesgo de infección" @default.
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