SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W117058047> ?p ?o ?g. }

Showing items 1 to 84 of 84 with 100 items per page.

W117058047 endingPage "186" @default.
W117058047 startingPage "173" @default.
W117058047 abstract "Hepatic gene therapy may provide a new approach to treating hepatic malignancies. A promising strategy involves the infection of tumor and liver cells with replication-defective adenoviral vectors carrying suicide genes. The products of these genes convert prodrugs into cytotoxic derivates. In the transduced cells the subsequently administered prodrugs are thus activated and destroy replicating tumor cells, whereas the infected liver cells are thought to be unaffected because of their minimal proliferative activity. A major concern about this approach is that the suicide genes can theoretically enter the germline and other organs with high mitotic activity and as a consequence, cause their destruction. In vivo gene delivery should therefore be tissue-specific, and methods for targeted gene delivery are required. Targeting the colorectal liver metastases is pursued by combining the suicide gene principle and the surgical technique of isolated perfusion of the liver.KeywordsGene TherapyThymidine KinaseColorectal Liver MetastasisCC531 CellSuicide GeneThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
W117058047 created "2016-06-24" @default.
W117058047 creator A5005383720 @default.
W117058047 creator A5021828078 @default.
W117058047 creator A5026031837 @default.
W117058047 date "1998-01-01" @default.
W117058047 modified "2023-10-15" @default.
W117058047 title "Towards Gene Therapy for Colorectal Liver Metastases" @default.
W117058047 cites W1965295123 @default.
W117058047 cites W1965372133 @default.
W117058047 cites W1980401440 @default.
W117058047 cites W1980424217 @default.
W117058047 cites W1994361021 @default.
W117058047 cites W1998290936 @default.
W117058047 cites W1999369189 @default.
W117058047 cites W2009123070 @default.
W117058047 cites W2013359336 @default.
W117058047 cites W2015617337 @default.
W117058047 cites W2016138321 @default.
W117058047 cites W2019754652 @default.
W117058047 cites W2034076812 @default.
W117058047 cites W2036650398 @default.
W117058047 cites W2058106591 @default.
W117058047 cites W2073809951 @default.
W117058047 cites W2083430062 @default.
W117058047 cites W2087943611 @default.
W117058047 cites W2106316486 @default.
W117058047 cites W2166797660 @default.
W117058047 doi "https://doi.org/10.1007/978-3-642-80460-1_16" @default.
W117058047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9670278" @default.
W117058047 hasPublicationYear "1998" @default.
W117058047 type Work @default.
W117058047 sameAs 117058047 @default.
W117058047 citedByCount "7" @default.
W117058047 crossrefType "book-chapter" @default.
W117058047 hasAuthorship W117058047A5005383720 @default.
W117058047 hasAuthorship W117058047A5021828078 @default.
W117058047 hasAuthorship W117058047A5026031837 @default.
W117058047 hasConcept C104317684 @default.
W117058047 hasConcept C108215921 @default.
W117058047 hasConcept C111599444 @default.
W117058047 hasConcept C135983454 @default.
W117058047 hasConcept C154317977 @default.
W117058047 hasConcept C202751555 @default.
W117058047 hasConcept C207001950 @default.
W117058047 hasConcept C34981463 @default.
W117058047 hasConcept C502942594 @default.
W117058047 hasConcept C54355233 @default.
W117058047 hasConcept C71924100 @default.
W117058047 hasConcept C86803240 @default.
W117058047 hasConcept C98274493 @default.
W117058047 hasConceptScore W117058047C104317684 @default.
W117058047 hasConceptScore W117058047C108215921 @default.
W117058047 hasConceptScore W117058047C111599444 @default.
W117058047 hasConceptScore W117058047C135983454 @default.
W117058047 hasConceptScore W117058047C154317977 @default.
W117058047 hasConceptScore W117058047C202751555 @default.
W117058047 hasConceptScore W117058047C207001950 @default.
W117058047 hasConceptScore W117058047C34981463 @default.
W117058047 hasConceptScore W117058047C502942594 @default.
W117058047 hasConceptScore W117058047C54355233 @default.
W117058047 hasConceptScore W117058047C71924100 @default.
W117058047 hasConceptScore W117058047C86803240 @default.
W117058047 hasConceptScore W117058047C98274493 @default.
W117058047 hasLocation W1170580471 @default.
W117058047 hasLocation W1170580472 @default.
W117058047 hasOpenAccess W117058047 @default.
W117058047 hasPrimaryLocation W1170580471 @default.
W117058047 hasRelatedWork W1516372724 @default.
W117058047 hasRelatedWork W1963729009 @default.
W117058047 hasRelatedWork W1967228566 @default.
W117058047 hasRelatedWork W2037105618 @default.
W117058047 hasRelatedWork W2042625673 @default.
W117058047 hasRelatedWork W2044266853 @default.
W117058047 hasRelatedWork W2061760711 @default.
W117058047 hasRelatedWork W2073874669 @default.
W117058047 hasRelatedWork W2107439660 @default.
W117058047 hasRelatedWork W2158070520 @default.
W117058047 isParatext "false" @default.
W117058047 isRetracted "false" @default.
W117058047 magId "117058047" @default.
W117058047 workType "book-chapter" @default.