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- W117083775 abstract "1596 Objectives Previous investigations have shown that interleukin-11 (IL-11) and the IL-11 receptor (IL-11R) have been correlated with the regulation of tumor progression and may play a significant role in the bone metastases. The nonapeptide structure c(CGRRAGGSC) is a phage-display-selected IL-11 mimic binding to IL-11R. The aim of this study was to synthesize radiolabeled c(CGRRAGGSC) conjugation IL-11R and to assess the interaction between this radioactive probe and IL-11R positive bone metastasis models of PC-3 prostate cancer Methods Radioactive molecular probe 99Tcm-DTPA-c(CGRRAGGSC) was radiolabeled with 99Tcm using the diethylenetriaminepentaacetic acid (DTPA) chelate. The binding characteristics of the labeling probe was analyzed using radioreceptor analyze. The γ imaging and biodistribution of the probe were investigated in nude mice PC-3 positive tumors xenografts at 0.5,1,2,4,6,8,24h after intravenous injection respectively Results The labeling product, 99Tcm-DTPA-c(CGRRAGGSC),has high labeling rate, high radiochemical purity and stability. Saturation and reversibility were observed in vitro; the Kd value was 0.32±0.02 nmol/L and Bmax value was 754±34 fmol/mg. Dynamic γ images showed the values of bone, tumor peaking at 4h after injection were 1.910±0.109 %ID/g and 15.645±0.027 %ID/g, respectively. The radioactive uptake remained at least 6-8 hours at the tumor region, peaking at 4h and totally disappeared at 24 h after injection. The tumor to normal ratios (T/NT) were 1.17±0.17 , 2.20±0.29, 3.20±0.15, 3.67±0.23, 13.61±0.85, 9.45±0.37 and 3.33±0.30, respectively, through the measurements for the regions of interest Conclusions The probe exhibited significantly high tumor uptake and tumor to normal issue ratios in vivo. Radioactive molecular probe 99Tcm-DTPA-c(CGRRAGGSC) has potential as a specific molecular target imaging agent for IL-11R over-expression tumors and bone metastasis, such as prostate cance" @default.
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- W117083775 date "2011-05-01" @default.
- W117083775 modified "2023-09-23" @default.
- W117083775 title "Preliminary study of a radiolabeled nonapeptide probe on the receptor imaging of bone metastases model of prostate cancer in mice" @default.
- W117083775 hasPublicationYear "2011" @default.
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