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- W1171942363 abstract "There is a clear need for renewed efforts to combat the increasing incidence of antibiotic resistance. While the antibiotic resistance epidemic is due in part to the misuse of antibiotics, even proper empiric antibiotic therapy increases the selective pressure and potential for drug-resistance and spread of resistance mechanisms between bacteria. Antibiotic resistance coupled with the detrimental effects of broad-spectrum antibiotics on the healthy microbiome, have led the field to explore pathogen specific antibacterials such as monoclonal antibodies (mAbs). Medical need along with advances in mAb discovery, engineering, and production have driven significant effort developing mAb-based antibacterials. If successful, they will provide physicians with precision weapons to combat bacterial infections and can help prevent a return to a pre-antibiotic era." @default.
- W1171942363 created "2016-06-24" @default.
- W1171942363 creator A5050859911 @default.
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- W1171942363 date "2015-10-01" @default.
- W1171942363 modified "2023-10-13" @default.
- W1171942363 title "Antibacterial monoclonal antibodies: the next generation?" @default.
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- W1171942363 doi "https://doi.org/10.1016/j.mib.2015.07.014" @default.
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