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- W117496733 abstract "The predominant chromosome translocations associated with Burkitt lymphomas of man and plasmacytomas of the mouse result from recombination of the c-myc protooncogene with the immunoglobulin heavy chain locus. The crucial outcome of this event is deregulation of c-myc expression. The hypothesis that constitutive myc expression highly predisposes to tumorigenesis has now been amply vindicated by studies with transgenic mice. Animals bearing a c-myc gene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma, Eμ being particularly effective. The lymphoid regulatory elements play an essential role because transgenic mice carrying either a “normal” c-myc gene or a gene lacking the putative 5′ regulatory region fail to develop tumors. The tumors in Eμ-myc mice are all B lymphoid in origin and monoclonal. Tumorigenesis is preceded by a benign polyclonal proliferation of early B lineage cells which is evident as early as 18 days of gestation. Characterization of this preneoplastic phase induced by the deregulated c-myc gene suggests that the level of c-myc expression is a crucial factor in determining the balance between self-renewal and maturation within a differentiation lineage." @default.
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- W117496733 date "1986-01-01" @default.
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- W117496733 title "Lessons from Translocations and Transgenic Mice: Constitutive c-myc Expression Predisposes to Neoplasia" @default.
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- W117496733 doi "https://doi.org/10.1016/b978-0-12-174685-8.50068-8" @default.
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