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• W117518344 endingPage "1977" @default.
• W117518344 startingPage "1974" @default.
• W117518344 abstract "Cloning and expression of the human Kv4.3 potassium channel. We report on the cloning and expression of hKv4.3, a fast inactivating, transient, A-type potassium channel found in both heart and brain that is 91% homologous to the rat Kv4.3 channel. Two isoforms of hKv4.3 were cloned. One is full length (hKv4.3 long), and the other has a 19 amino acid deletion (hKv4.3 short). RT-PCR shows that the brain contains both forms of the channel RNA, whereas the heart predominantly has the longer version. Both versions of the channel were expressed in Xenopus oocytes, and both contain a significant window or noninactivating current seen near potentials of −30 to −40 mV. The inactivation curve for hKv4.3 short is shifted 10 mV positive relative to hKv4.3 long. This causes the peak window current for the short version to occur near −30 mV and the peak for the longer version to be at −40 mV. There was little difference in the recovery from inactivation or in the kinetics of inactivation between the two isoforms of the channel." @default.
• W117518344 created "2016-06-24" @default.
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• W117518344 date "1999-04-01" @default.
• W117518344 modified "2023-10-16" @default.
• W117518344 title "Cloning and Expression of the Human Kv4.3 Potassium Channel" @default.
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• W117518344 doi "https://doi.org/10.1152/jn.1999.81.4.1974" @default.
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