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- W117558571 abstract "X irradiation of cells induces damage in the DNA, which can be detected as fragmentation of the DNA in alkali. To examine whether DNA polymerase alpha plays a role in the X-ray-induced fragmentation of the DNA, cells with and without functioning DNA polymerase alpha have been compared. We have used the drug aphidicolin, which is a specific inhibitor of polymerase alpha. The results show that DNA of aphidicolin-treated cells is more easily fragmented in alkali than DNA of untreated cells. This is paralleled by a lower repair replication in cells without functioning DNA polymerase alpha. Hence polymerase alpha is involved in the repair process of lesions induced by X irradiation." @default.
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- W117558571 date "1985-04-01" @default.
- W117558571 modified "2023-09-23" @default.
- W117558571 title "Reduced repair of X-ray-induced DNA lesions in cells without functioning DNA polymerase alpha." @default.
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