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- W117595221 abstract "We investigated the effects of various amino acids on responses to ATP-sensitive potassium (K ATP ) channel openers in anesthetized cats equipped with cranial windows. The application of pinacidil by superfusion caused transient vasodilation, whereas there was sustained vasodilation from the application of stationary solution of pinacidil. In the presence ofl-arginine orl-lysine, pinacidil by superfusion led to sustained vasodilation, suggesting that the rapid flow of fluid displaced these amino acids from binding on the channel and that such binding was essential for opening the channel. N G -nitro-l-arginine blocked responses to pinacidil, and this blockade was reversed byl-lysine orl-arginine but not byd-arginine,d-lysine, methyl-l-arginine, glycine,l-histidine, dimethylarginine, dimethyl-l-arginine, or hydroxylysine. The blockade of responses to pinacidil induced by glyburide was also reversed completely byl-arginine orl-lysine but not byd-arginine, suggesting that these amino acids act on the sulfonylurea receptor. Hydroxylysine but not methyl-l-lysine, dimethylarginine, or dimethyl-l-arginine blocked responses to pinacidil. The findings show that K ATP channels in cerebral arterioles need l-lysine orl-arginine to open in response to agonists." @default.
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- W117595221 date "1998-03-01" @default.
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- W117595221 title "Cerebral arteriolar dilations by KATP channel activators needl-lysine orl-arginine" @default.
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- W117595221 doi "https://doi.org/10.1152/ajpheart.1998.274.3.h974" @default.
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