Matches in SemOpenAlex for { <https://semopenalex.org/work/W1176278669> ?p ?o ?g. }
- W1176278669 abstract "Breastmilk is a rich source of cells with a heterogeneous composition comprising early-stage stem cells, progenitors and more differentiated cells. The gene expression profiles of these cells and their associations with characteristics of the breastfeeding mother and infant are poorly understood. This study investigated factors associated with the cellular dynamics of breastmilk and explored variations amongst women. Genes representing different breastmilk cell populations including mammary epithelial and myoepithelial cells, progenitors, and multi-lineage stem cells showed great variation in expression. Stem cell markers ESRRB and CK5, myoepithelial marker CK14, and lactocyte marker α-lactalbumin were amongst the genes most highly expressed across all samples tested. Genes exerting similar functions, such as either stem cell regulation or milk production, were found to be closely associated. Infant gestational age at delivery and changes in maternal bra cup size between pre-pregnancy and postpartum lactation were associated with expression of genes controlling stemness as well as milk synthesis. Additional correlations were found between genes and dyad characteristics, which may explain abnormalities related to low breastmilk supply or preterm birth. Our findings highlight the heterogeneity of breastmilk cell content and its changes associated with characteristics of the breastfeeding dyad that may reflect changing infant needs." @default.
- W1176278669 created "2016-06-24" @default.
- W1176278669 creator A5000733521 @default.
- W1176278669 creator A5003942091 @default.
- W1176278669 creator A5017501856 @default.
- W1176278669 creator A5022898788 @default.
- W1176278669 creator A5024634924 @default.
- W1176278669 creator A5025127000 @default.
- W1176278669 creator A5046365594 @default.
- W1176278669 creator A5053679702 @default.
- W1176278669 creator A5085455963 @default.
- W1176278669 date "2015-08-10" @default.
- W1176278669 modified "2023-09-30" @default.
- W1176278669 title "Gene expression in breastmilk cells is associated with maternal and infant characteristics" @default.
- W1176278669 cites W1513618424 @default.
- W1176278669 cites W1542090274 @default.
- W1176278669 cites W1902397148 @default.
- W1176278669 cites W1927705775 @default.
- W1176278669 cites W1967325957 @default.
- W1176278669 cites W1974769224 @default.
- W1176278669 cites W1976117245 @default.
- W1176278669 cites W1977349323 @default.
- W1176278669 cites W1985277375 @default.
- W1176278669 cites W1988987474 @default.
- W1176278669 cites W1990554423 @default.
- W1176278669 cites W1990718295 @default.
- W1176278669 cites W1992107766 @default.
- W1176278669 cites W2000079492 @default.
- W1176278669 cites W2006321432 @default.
- W1176278669 cites W2010867675 @default.
- W1176278669 cites W2012355682 @default.
- W1176278669 cites W2013003658 @default.
- W1176278669 cites W2015811901 @default.
- W1176278669 cites W2022558816 @default.
- W1176278669 cites W2023508819 @default.
- W1176278669 cites W2025319925 @default.
- W1176278669 cites W2045608491 @default.
- W1176278669 cites W2046983705 @default.
- W1176278669 cites W2058640723 @default.
- W1176278669 cites W2060299616 @default.
- W1176278669 cites W2063506958 @default.
- W1176278669 cites W2072904631 @default.
- W1176278669 cites W2076457965 @default.
- W1176278669 cites W2076612253 @default.
- W1176278669 cites W2082063257 @default.
- W1176278669 cites W2085832350 @default.
- W1176278669 cites W2087586321 @default.
- W1176278669 cites W2089984611 @default.
- W1176278669 cites W2094833794 @default.
- W1176278669 cites W2095903869 @default.
- W1176278669 cites W2096251024 @default.
- W1176278669 cites W2097164719 @default.
- W1176278669 cites W2098237452 @default.
- W1176278669 cites W2098290597 @default.
- W1176278669 cites W2104176482 @default.
- W1176278669 cites W2105176668 @default.
- W1176278669 cites W2105181422 @default.
- W1176278669 cites W2106626003 @default.
- W1176278669 cites W2107734673 @default.
- W1176278669 cites W2111062014 @default.
- W1176278669 cites W2123168484 @default.
- W1176278669 cites W2124218468 @default.
- W1176278669 cites W2133445155 @default.
- W1176278669 cites W2137920359 @default.
- W1176278669 cites W2138977668 @default.
- W1176278669 cites W2144962713 @default.
- W1176278669 cites W2145399001 @default.
- W1176278669 cites W2154707264 @default.
- W1176278669 cites W2155311479 @default.
- W1176278669 cites W2156426485 @default.
- W1176278669 cites W2159064954 @default.
- W1176278669 cites W2161810908 @default.
- W1176278669 cites W2166359423 @default.
- W1176278669 cites W2166747583 @default.
- W1176278669 cites W2167378362 @default.
- W1176278669 cites W2444484448 @default.
- W1176278669 cites W4248779100 @default.
- W1176278669 doi "https://doi.org/10.1038/srep12933" @default.
- W1176278669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4542700" @default.
- W1176278669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26255679" @default.
- W1176278669 hasPublicationYear "2015" @default.
- W1176278669 type Work @default.
- W1176278669 sameAs 1176278669 @default.
- W1176278669 citedByCount "68" @default.
- W1176278669 countsByYear W11762786692015 @default.
- W1176278669 countsByYear W11762786692016 @default.
- W1176278669 countsByYear W11762786692017 @default.
- W1176278669 countsByYear W11762786692018 @default.
- W1176278669 countsByYear W11762786692019 @default.
- W1176278669 countsByYear W11762786692020 @default.
- W1176278669 countsByYear W11762786692021 @default.
- W1176278669 countsByYear W11762786692022 @default.
- W1176278669 countsByYear W11762786692023 @default.
- W1176278669 crossrefType "journal-article" @default.
- W1176278669 hasAuthorship W1176278669A5000733521 @default.
- W1176278669 hasAuthorship W1176278669A5003942091 @default.
- W1176278669 hasAuthorship W1176278669A5017501856 @default.
- W1176278669 hasAuthorship W1176278669A5022898788 @default.
- W1176278669 hasAuthorship W1176278669A5024634924 @default.
- W1176278669 hasAuthorship W1176278669A5025127000 @default.