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• W1176298813 endingPage "8049" @default.
• W1176298813 startingPage "8044" @default.
• W1176298813 abstract "Inorganic nanomaterials have been increasingly utilized in many consumer products, which has led to concerns about their potential toxicity. At present, there is limited knowledge about the gastrointestinal fate and cytotoxicity of ingested inorganic nanoparticles. This study determined the influence of particle size and concentration of gold nanoparticles (AuNPs) on their absorption, accumulation, and cytotoxicity in model intestinal epithelial cells. As the mean particle diameter of the AuNPs decreased (from 100 to 50 to 15 nm), their rate of absorption by the intestinal epithelium cells increased, but their cellular accumulation in the epithelial cells decreased. Moreover, accumulation of AuNPs caused cytotoxicity in the intestinal epithelial cells, which was evidenced by depolarization of mitochondria membranes. These results provide important insights into the relationship between the dimensions of AuNPs and their gastrointestinal uptake and potential cytotoxicity." @default.
• W1176298813 created "2016-06-24" @default.
• W1176298813 creator A5012889558 @default.
• W1176298813 creator A5019873745 @default.
• W1176298813 creator A5053615429 @default.
• W1176298813 creator A5073068394 @default.
• W1176298813 date "2015-09-02" @default.
• W1176298813 modified "2023-09-29" @default.
• W1176298813 title "Uptake of Gold Nanoparticles by Intestinal Epithelial Cells: Impact of Particle Size on Their Absorption, Accumulation, and Toxicity" @default.
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• W1176298813 doi "https://doi.org/10.1021/acs.jafc.5b03242" @default.
• W1176298813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26313743" @default.
• W1176298813 hasPublicationYear "2015" @default.
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